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10.1101/gad.287540.116 http://scihub22266oqcxt.onion/10.1101/gad.287540.116 C5159662!5159662 !27940961     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27940961 &cmd=llinks): Failed to open stream: HTTP request failed! 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IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer |pdf=|usr=}}{{27940961 }} gab.com Text IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=27940961 #FOAvip IMPs, also known as insulin-like growth factor 2 (IGF2) messenger RNA (mRNA)-binding proteins (IGF2BPs), are highly conserved oncofetal RNA-binding proteins (RBPs) that regulate RNA processing at several levels, including localization, translation, and stability. Three mammalian IMP paralogs (IMP1-3) have been identified that are expressed in most organs during embryogenesis, where they are believed to play an important role in cell migration, metabolism, and stem cell renewal. Whereas some IMP2 expression is retained in several adult mouse organs, IMP1 and IMP3 are either absent or expressed at very low levels in most tissues after birth. However, all three paralogs can be re-expressed upon malignant transformation and are found in a broad range of cancer types where their expression often correlates with poor prognosis. IMPs appear to resume their physiological functions in malignant cells, which not only contribute to tumor progression but participate in the establishment and maintenance of tumor cell hierarchies. This review summarizes our current understanding of the functions of IMPs during normal development and focuses on a series of recent observations that have provided new insight into how their physiological functions enable IMPs to play a potentially key role in cancer stem cell maintenance and tumor growth. Twit Text FOAVip IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=27940961 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27940961 #FOAvip English Wikipedia <ref>{{Cite pmid|27940961 }}</ref> IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer #MMPMID27940961 Degrauwe N ; Suvā ML ; Janiszewska M ; Riggi N ; Stamenkovic I Genes Dev 2016[Nov]; 30 (22 ): 2459-2474 PMID27940961 show ga IMPs, also known as insulin-like growth factor 2 (IGF2) messenger RNA (mRNA)-binding proteins (IGF2BPs), are highly conserved oncofetal RNA-binding proteins (RBPs) that regulate RNA processing at several levels, including localization, translation, and stability. Three mammalian IMP paralogs (IMP1-3) have been identified that are expressed in most organs during embryogenesis, where they are believed to play an important role in cell migration, metabolism, and stem cell renewal. Whereas some IMP2 expression is retained in several adult mouse organs, IMP1 and IMP3 are either absent or expressed at very low levels in most tissues after birth. However, all three paralogs can be re-expressed upon malignant transformation and are found in a broad range of cancer types where their expression often correlates with poor prognosis. IMPs appear to resume their physiological functions in malignant cells, which not only contribute to tumor progression but participate in the establishment and maintenance of tumor cell hierarchies. This review summarizes our current understanding of the functions of IMPs during normal development and focuses on a series of recent observations that have provided new insight into how their physiological functions enable IMPs to play a potentially key role in cancer stem cell maintenance and tumor growth. |Animals [MESH] |Embryonic Development/*genetics [MESH] |Gene Expression Regulation, Developmental [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Neoplasms/*genetics/*physiopathology [MESH] |RNA Processing, Post-Transcriptional/genetics [MESH] |RNA-Binding Proteins/genetics/*metabolism [MESH]IMPs: an RNA-binding protein family that provides a link between stem (epmc).pdf DeepDyve Pubget Overpricing