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10.1016/j.clim.2016.07.007

http://scihub22266oqcxt.onion/10.1016/j.clim.2016.07.007
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suck abstract from ncbi


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pmid27430519
      Clin+Immunol 2016 ; 172 (ä): 65-71
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  • "Lupoid hepatitis" in SLE patients and mice with experimental lupus #MMPMID27430519
  • Shumyak S ; Yang LJ ; Han S ; Zhuang H ; Reeves WH
  • Clin Immunol 2016[Nov]; 172 (ä): 65-71 PMID27430519 show ga
  • The unusual subset of patients with severe hepatitis, hypergammaglobulinemia, arthritis, and LE cells in the blood reported by Henry Kunkel and others suggested to these investigators that "lupoid" hepatitis might share pathogenic mechanisms with SLE. More than half a century later, the etiology of autoimmune hepatitis remains unclear. The occurrence of autoimmune hepatitis in a small fraction (about 3%) of SLE patients in our lupus cohort and in two mouse models of SLE supports their conclusion that lupoid hepatitis may be share pathogenic mechanisms with SLE. The development of autoimmune hepatitis in mice with pristane-induced lupus provides an opportunity to further explore the potential link between these two autoimmune disorders.
  • |*Hepatitis, Autoimmune/blood/immunology/pathology [MESH]
  • |*Lupus Erythematosus, Systemic/blood/chemically induced/immunology/pathology [MESH]
  • |Actins/immunology [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Animals [MESH]
  • |Autoantibodies/blood [MESH]
  • |Disease Models, Animal [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Immunoglobulin G/blood [MESH]
  • |Liver/pathology [MESH]
  • |Mice, Inbred BALB C [MESH]
  • |Mice, Inbred C57BL [MESH]
  • |Middle Aged [MESH]
  • |Muscle, Smooth/immunology [MESH]
  • |Serum Globulins/analysis [MESH]
  • |Terpenes [MESH]


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