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2016 ; 172
(ä): 65-71
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"Lupoid hepatitis" in SLE patients and mice with experimental lupus
#MMPMID27430519
Shumyak S
; Yang LJ
; Han S
; Zhuang H
; Reeves WH
Clin Immunol
2016[Nov]; 172
(ä): 65-71
PMID27430519
show ga
The unusual subset of patients with severe hepatitis, hypergammaglobulinemia,
arthritis, and LE cells in the blood reported by Henry Kunkel and others
suggested to these investigators that "lupoid" hepatitis might share pathogenic
mechanisms with SLE. More than half a century later, the etiology of autoimmune
hepatitis remains unclear. The occurrence of autoimmune hepatitis in a small
fraction (about 3%) of SLE patients in our lupus cohort and in two mouse models
of SLE supports their conclusion that lupoid hepatitis may be share pathogenic
mechanisms with SLE. The development of autoimmune hepatitis in mice with
pristane-induced lupus provides an opportunity to further explore the potential
link between these two autoimmune disorders.