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10.1016/j.it.2016.08.010

http://scihub22266oqcxt.onion/10.1016/j.it.2016.08.010
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C5159193!5159193!27614798
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suck abstract from ncbi


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pmid27614798      Trends+Immunol 2016 ; 37 (11): 724-37
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  • Present Yourself! By MHC Class I and MHC Class II Molecules #MMPMID27614798
  • Rock KL; Reits E; Neefjes J
  • Trends Immunol 2016[Nov]; 37 (11): 724-37 PMID27614798show ga
  • Since the discovery of major histocompatibility complex (MHC) molecules, it took some 40 years to arrive at a coherent picture of how MHC class I and MHC class II molecules really work. This is a story of proteases and MHC-like chaperones that support the MHC class I and II molecules in presenting peptides to the immune system. We now understand that the MHC system shapes both the repertoire of presented peptides and the subsequent T cell responses, with important implications ranging from transplant rejection to tumor immunotherapies. Here we present an illustrated review on the ins and outs of MHC class I and MHC class II antigen presentation.
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