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10.1084/jem.20151620 http://scihub22266oqcxt.onion/10.1084/jem.20151620 C5154933!5154933 !27849553     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27849553 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2016 ; 213 (13 ): 3025-3039 Nephropedia Template TP {{tp|p=27849553 |t=2016. STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria |pdf=|usr=}}{{27849553 }} gab.com Text STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27849553 #FOAvip Marginal zone B (MZ B) cells can rapidly produce antibody in response to infection with blood-borne encapsulated pathogens. Although TLR-mediated activation of MZ B is known to trigger humoral immune response, the signal cascade directing this response remains undefined. Here, we demonstrate that STAT1 plays an essential role in TLR-mediated antibody response of MZ B cells. Further, the TLR-induced IgM response is impaired in a type I and type II IFN-independent manner. Although activation, proliferation, and apoptosis are not affected, both differentiation into plasma cells and IgM production are impaired in Stat1(-/-) MZ B cells. Interestingly, STAT1 directly regulates the expression of Prdm1 (encodes BLIMP-1) by binding to its promoter, and Prdm1 expression is reduced in Stat1(-/-) MZ B cells. Restoration of BLIMP-1 to cells rescues TLR-induced IgM response. Moreover, Stat1(-/-) mice are more susceptible to S. pneumoniae infection, which can be rescued by the serum of bacteria-primed WT mice. The increased susceptibility to S. pneumoniae infection in Stat1(-/-) mice is also intrinsic to STAT1 requirement in MZ B cells. Collectively, these results define a differential regulation of TLR-mediated activation and differentiation of MZ B cells by STAT1 and reveal a STAT1-dependent, but IFN-independent, antibody response during infection and inflammation. Twit Text FOAVip STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27849553 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27849553 #FOAvip English Wikipedia <ref>{{Cite pmid|27849553 }}</ref> STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria #MMPMID27849553 Chen TT ; Tsai MH ; Kung JT ; Lin KI ; Decker T ; Lee CK J Exp Med 2016[Dec]; 213 (13 ): 3025-3039 PMID27849553 show ga Marginal zone B (MZ B) cells can rapidly produce antibody in response to infection with blood-borne encapsulated pathogens. Although TLR-mediated activation of MZ B is known to trigger humoral immune response, the signal cascade directing this response remains undefined. Here, we demonstrate that STAT1 plays an essential role in TLR-mediated antibody response of MZ B cells. Further, the TLR-induced IgM response is impaired in a type I and type II IFN-independent manner. Although activation, proliferation, and apoptosis are not affected, both differentiation into plasma cells and IgM production are impaired in Stat1(-/-) MZ B cells. Interestingly, STAT1 directly regulates the expression of Prdm1 (encodes BLIMP-1) by binding to its promoter, and Prdm1 expression is reduced in Stat1(-/-) MZ B cells. Restoration of BLIMP-1 to cells rescues TLR-induced IgM response. Moreover, Stat1(-/-) mice are more susceptible to S. pneumoniae infection, which can be rescued by the serum of bacteria-primed WT mice. The increased susceptibility to S. pneumoniae infection in Stat1(-/-) mice is also intrinsic to STAT1 requirement in MZ B cells. Collectively, these results define a differential regulation of TLR-mediated activation and differentiation of MZ B cells by STAT1 and reveal a STAT1-dependent, but IFN-independent, antibody response during infection and inflammation. |*Blood-Borne Pathogens [MESH] |Animals [MESH] |B-Lymphocytes/*immunology/pathology [MESH] |Cell Differentiation/genetics/*immunology [MESH] |Inflammation/genetics/immunology/pathology [MESH] |Interferons/genetics/immunology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Pneumococcal Infections/genetics/*immunology/pathology [MESH] |Positive Regulatory Domain I-Binding Factor 1 [MESH] |STAT1 Transcription Factor/genetics/*immunology [MESH] |Streptococcus pneumoniae/*immunology [MESH]STAT1 regulates marginal zone B cell differentiation in response to in(epmc).pdf DeepDyve Pubget Overpricing