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2012 ; 5
(4
): 718
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Omega-3 Polyunsaturated Fatty Acid Supplementation: Mechanism and Current
Evidence in Atrial Fibrillation
#MMPMID28496797
Nodari S
; Triggiani M
; Campia U
; Dei Cas L
J Atr Fibrillation
2012[Dec]; 5
(4
): 718
PMID28496797
show ga
Atrial fibrillation (AF) is the most prevalent arrhythmia and is associated with
considerable morbidity and mortality. Available pharmacologic antiarrhythmic
therapies are often ineffective in preventing the recurrence of AF, possibly
because these drugs target a single pathophysiological mechanism. Given their
beneficial effects on ventricular arrhythmias, omega-3 polyunsaturated fatty
acids (n-3 PUFAs) have recently been investigated as possible candidates in the
treatment of supraventricular arrhythmias. In this review, we explore the current
understanding of the antiarrhythmic effects attributed to n-3 PUFAs including
direct modulation of ionic channels, improvement of membrane fluidity,
anti-inflammatory and antifibrotic effects, and modulation of sympatho-vagal
balance. We will then focus on the results of epidemiologic studies exploring the
associations between nutritional intake of n3 PUFAs and the incidence of AF, and
will review the findings of the clinical trials investigating the effects of n-3
PUFAs supplementation in the prophylaxis of AF and in the prevention of its
recurrences.