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10.1038/nature20165 http://scihub22266oqcxt.onion/10.1038/nature20165 C5149074!5149074!27798602     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2016 ; 540 (7632): 236-41 Nephropedia Template TP {{tp|p=27798602|t=2016. The immunometabolite S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate |pdf=|usr=}}{{27798602}} gab.com Text The immunometabolite S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=27798602 #FOAvip R-2-hydroxyglutarate accumulates to millimolar levels in cancers with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both R- and S-2-hydroxyglutarate, the other enantiomer of this metabolite, are detectible in healthy individuals, yet their physiological function remains elusive. Here we show that CD8+ T-lymphocytes accumulate 2-hydroxyglutarate in response to T-cell receptor triggering. This increases to millimolar levels in physiological oxygen conditions, via a hypoxia inducible factor 1 alpha-dependent mechanism. S-2-hydroxyglutarate predominates over R-2-hydroxyglutarate in activated T cells, and we demonstrate alterations in markers of CD8+ T-lymphocyte differentiation in response to this metabolite. Modulation of histone and DNA demethylation as well as hypoxia inducible factor 1 alpha stability mediate these effects. S-2-hydroxyglutarate treatment greatly enhances the in vivo proliferation, persistence and anti-tumour capacity of adoptively transferred CD8+ T-lymphocytes. Thus S-2-hydroxyglutarate acts as an immunometabolite that links environmental context, via a metabolic-epigenetic axis, to immune fate and function. Twit Text FOAVip The immunometabolite S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=27798602 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27798602 #FOAvip English Wikipedia <ref>{{Cite pmid|27798602}}</ref> The immunometabolite S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate #MMPMID27798602 Tyrakis PA; Palazon A; Macias D; Lee KL; Phan AT; Veliça P; You J; Chia GS; Sim J; Doedens A; Abelanet A; Evans CE; Griffiths JR; Poellinger L; Goldrath AW; Johnson RS Nature 2016[Dec]; 540 (7632): 236-41 PMID27798602show ga R-2-hydroxyglutarate accumulates to millimolar levels in cancers with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both R- and S-2-hydroxyglutarate, the other enantiomer of this metabolite, are detectible in healthy individuals, yet their physiological function remains elusive. Here we show that CD8+ T-lymphocytes accumulate 2-hydroxyglutarate in response to T-cell receptor triggering. This increases to millimolar levels in physiological oxygen conditions, via a hypoxia inducible factor 1 alpha-dependent mechanism. S-2-hydroxyglutarate predominates over R-2-hydroxyglutarate in activated T cells, and we demonstrate alterations in markers of CD8+ T-lymphocyte differentiation in response to this metabolite. Modulation of histone and DNA demethylation as well as hypoxia inducible factor 1 alpha stability mediate these effects. S-2-hydroxyglutarate treatment greatly enhances the in vivo proliferation, persistence and anti-tumour capacity of adoptively transferred CD8+ T-lymphocytes. Thus S-2-hydroxyglutarate acts as an immunometabolite that links environmental context, via a metabolic-epigenetic axis, to immune fate and function. äThe immunometabolite S-2-hydroxyglutarate regulates CD8+ T-lymphocyte (epmc).pdf DeepDyve Pubget Overpricing