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10.1083/jcb.201606081 http://scihub22266oqcxt.onion/10.1083/jcb.201606081 C5147003!5147003 !27881713     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27881713 &cmd=llinks): Failed to open stream: HTTP request failed! 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GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK |pdf=|usr=}}{{27881713 }} gab.com Text GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27881713 #FOAvip The dynamic regulation of microtubules (MTs) during mitosis is critical for accurate chromosome segregation and genome stability. Cancer cell lines with hyperstabilized kinetochore MTs have increased segregation errors and elevated chromosomal instability (CIN), but the genetic defects responsible remain largely unknown. The MT depolymerase MCAK (mitotic centromere-associated kinesin) can influence CIN through its impact on MT stability, but how its potent activity is controlled in cells remains unclear. In this study, we show that GTSE1, a protein found overexpressed in aneuploid cancer cell lines and tumors, regulates MT stability during mitosis by inhibiting MCAK MT depolymerase activity. Cells lacking GTSE1 have defects in chromosome alignment and spindle positioning as a result of MT instability caused by excess MCAK activity. Reducing GTSE1 levels in CIN cancer cell lines reduces chromosome missegregation defects, whereas artificially inducing GTSE1 levels in chromosomally stable cells elevates chromosome missegregation and CIN. Thus, GTSE1 inhibition of MCAK activity regulates the balance of MT stability that determines the fidelity of chromosome alignment, segregation, and chromosomal stability. Twit Text FOAVip GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27881713 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27881713 #FOAvip English Wikipedia <ref>{{Cite pmid|27881713 }}</ref> GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK #MMPMID27881713 Bendre S ; Rondelet A ; Hall C ; Schmidt N ; Lin YC ; Brouhard GJ ; Bird AW J Cell Biol 2016[Dec]; 215 (5 ): 631-647 PMID27881713 show ga The dynamic regulation of microtubules (MTs) during mitosis is critical for accurate chromosome segregation and genome stability. Cancer cell lines with hyperstabilized kinetochore MTs have increased segregation errors and elevated chromosomal instability (CIN), but the genetic defects responsible remain largely unknown. The MT depolymerase MCAK (mitotic centromere-associated kinesin) can influence CIN through its impact on MT stability, but how its potent activity is controlled in cells remains unclear. In this study, we show that GTSE1, a protein found overexpressed in aneuploid cancer cell lines and tumors, regulates MT stability during mitosis by inhibiting MCAK MT depolymerase activity. Cells lacking GTSE1 have defects in chromosome alignment and spindle positioning as a result of MT instability caused by excess MCAK activity. Reducing GTSE1 levels in CIN cancer cell lines reduces chromosome missegregation defects, whereas artificially inducing GTSE1 levels in chromosomally stable cells elevates chromosome missegregation and CIN. Thus, GTSE1 inhibition of MCAK activity regulates the balance of MT stability that determines the fidelity of chromosome alignment, segregation, and chromosomal stability. |*Chromosome Segregation [MESH] |Anaphase [MESH] |Cell Line, Tumor [MESH] |Chromosomal Instability [MESH] |Chromosomes, Human/metabolism [MESH] |Guanosine Triphosphate/analogs & derivatives/metabolism [MESH] |Humans [MESH] |Kinesins/*metabolism [MESH] |Kinetochores/metabolism [MESH] |Microtubule-Associated Proteins/*metabolism [MESH] |Microtubules/*metabolism [MESH] |Mitosis [MESH] |Protein Binding [MESH]GTSE1 tunes microtubule stability for chromosome alignment and segrega(epmc).pdf DeepDyve Pubget Overpricing