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10.1007/s00784-015-1556-7 http://scihub22266oqcxt.onion/10.1007/s00784-015-1556-7 C5146953!5146953!26264638     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Oral+Investig 2016 ; 20 (4): 675-83 Nephropedia Template TP {{tp|p=26264638|t=2016. Citrullination in the periodontium ? a possible link between periodontitis and rheumatoid arthritis |pdf=|usr=}}{{26264638}} gab.com Text Citrullination in the periodontium a possible link between periodontitis and rheumatoid arthritis JO: Clin Oral Investig http://www.kidney.de/pget.php?&tw=1&pmid=26264638 #FOAvip Objectives: The aim of the present study was to assess human and bacterial peptidylarginine deiminase (PAD) activity in the gingival crevicular fluid (GCF) in the context of serum levels of antibodies against citrullinated epitopes in rheumatoid arthritis and periodontitis. Materials and Methods: Human PAD and Porphyromonas gingivalis-derived enzyme (PPAD) activities were measured in the GCF of 52 rheumatoid arthritis (RA) patients (48 with periodontitis and four without) and 44 non-RA controls (28 with periodontitis and 16 without). Serum antibodies against citrullinated epitopes were measured by ELISA. Bacteria being associated with periodontitis were determined by nucleic-acid based methods. Results: Citrullination was present in 26 (50%) RA patients and 23 (48%) controls. PAD and PPAD activities were detected in 36 (69%) and 30 (58%) RA patients, respectively, and in 30 (68%) and 21 (50%) controls, respectively. PPAD activity was higher in RA and non-RA patients with periodontitis than in those without (p = 0.038; p = 0.004), and was detected in 35 of 59 P. gingivalis positive samples, and in in 16 of 37 P. gingivalis-negative samples in association with high antibody levels against that species. Conclusions: PAD and PPAD activities within the periodontium are elevated in RA and non-RA patients with periodontitis. PPAD secreted by P. gingivalis residing in epithelial cells may exert its citrullinating activity in distant regions of the periodontium or even distant tissues. Clinical relevance: In periodontitis, the citrullination of proteins/peptides by human and bacterial peptidylarginine deiminases may generate antibodies after breaching immunotolerance in susceptible individuals. Twit Text FOAVip Citrullination in the periodontium a possible link between periodontitis and rheumatoid arthritis ????Clin Oral Investig http://www.kidney.de/pget.php?&tw=1&pmid=26264638 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26264638 #FOAvip English Wikipedia <ref>{{Cite pmid|26264638}}</ref> Citrullination in the periodontium ? a possible link between periodontitis and rheumatoid arthritis #MMPMID26264638 Laugisch O; Wong A; Sroka A; Kantyka T; Koziel J; Neuhaus K; Sculean A; Venables PJ; Potempa J; Möller B; Eick S Clin Oral Investig 2016[May]; 20 (4): 675-83 PMID26264638show ga Objectives: The aim of the present study was to assess human and bacterial peptidylarginine deiminase (PAD) activity in the gingival crevicular fluid (GCF) in the context of serum levels of antibodies against citrullinated epitopes in rheumatoid arthritis and periodontitis. Materials and Methods: Human PAD and Porphyromonas gingivalis-derived enzyme (PPAD) activities were measured in the GCF of 52 rheumatoid arthritis (RA) patients (48 with periodontitis and four without) and 44 non-RA controls (28 with periodontitis and 16 without). Serum antibodies against citrullinated epitopes were measured by ELISA. Bacteria being associated with periodontitis were determined by nucleic-acid based methods. Results: Citrullination was present in 26 (50%) RA patients and 23 (48%) controls. PAD and PPAD activities were detected in 36 (69%) and 30 (58%) RA patients, respectively, and in 30 (68%) and 21 (50%) controls, respectively. PPAD activity was higher in RA and non-RA patients with periodontitis than in those without (p = 0.038; p = 0.004), and was detected in 35 of 59 P. gingivalis positive samples, and in in 16 of 37 P. gingivalis-negative samples in association with high antibody levels against that species. Conclusions: PAD and PPAD activities within the periodontium are elevated in RA and non-RA patients with periodontitis. PPAD secreted by P. gingivalis residing in epithelial cells may exert its citrullinating activity in distant regions of the periodontium or even distant tissues. Clinical relevance: In periodontitis, the citrullination of proteins/peptides by human and bacterial peptidylarginine deiminases may generate antibodies after breaching immunotolerance in susceptible individuals. äCitrullination in the periodontium ? a possible link between periodont(epmc).pdf DeepDyve Pubget Overpricing