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10.1093/infdis/jiw448

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suck abstract from ncbi


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pmid27655870      J+Infect+Dis 2016 ; 214 (11): 1666-71
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  • Increased Proinflammatory Responses of Monocytes and Plasmacytoid Dendritic Cells to Influenza A Virus Infection During Pregnancy #MMPMID27655870
  • Le Gars M; Kay AW; Bayless NL; Aziz N; Dekker CL; Swan GE; Davis MM; Blish CA
  • J Infect Dis 2016[Dec]; 214 (11): 1666-71 PMID27655870show ga
  • Pregnancy-induced alterations in immunity may contribute to the increased morbidity associated with influenza A virus infection during pregnancy. We characterized the immune response of monocytes and plasmacytoid dendritic cells (pDCs) to influenza A virus infection in 21 pregnant and 21 nonpregnant women. In pregnant women, monocytes and pDCs exhibit an exaggerated proinflammatory immune response to 2 strains of influenza A virus, compared with nonpregnant women, characterized by increased expression of major histocompatibility complex class II (approximately 2.0-fold), CD69 (approximately 2.2-fold), interferon ??induced protein 10 (approximately 2.0-fold), and macrophage inflammatory protein 1? (approximately 1.5-fold). This enhanced innate inflammatory response during pregnancy could contribute to pulmonary inflammation following influenza A virus infection.
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