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10.1093/infdis/jiw448

http://scihub22266oqcxt.onion/10.1093/infdis/jiw448
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suck abstract from ncbi


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pmid27655870
      J+Infect+Dis 2016 ; 214 (11 ): 1666-1671
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  • Increased Proinflammatory Responses of Monocytes and Plasmacytoid Dendritic Cells to Influenza A Virus Infection During Pregnancy #MMPMID27655870
  • Le Gars M ; Kay AW ; Bayless NL ; Aziz N ; Dekker CL ; Swan GE ; Davis MM ; Blish CA
  • J Infect Dis 2016[Dec]; 214 (11 ): 1666-1671 PMID27655870 show ga
  • Pregnancy-induced alterations in immunity may contribute to the increased morbidity associated with influenza A virus infection during pregnancy. We characterized the immune response of monocytes and plasmacytoid dendritic cells (pDCs) to influenza A virus infection in 21 pregnant and 21 nonpregnant women. In pregnant women, monocytes and pDCs exhibit an exaggerated proinflammatory immune response to 2 strains of influenza A virus, compared with nonpregnant women, characterized by increased expression of major histocompatibility complex class II (approximately 2.0-fold), CD69 (approximately 2.2-fold), interferon ?-induced protein 10 (approximately 2.0-fold), and macrophage inflammatory protein 1? (approximately 1.5-fold). This enhanced innate inflammatory response during pregnancy could contribute to pulmonary inflammation following influenza A virus infection.
  • |Adult [MESH]
  • |Antigens, CD/analysis [MESH]
  • |Antigens, Differentiation, T-Lymphocyte/analysis [MESH]
  • |Chemokine CCL4/analysis [MESH]
  • |Chemokine CXCL10/analysis [MESH]
  • |Cytokines/*metabolism [MESH]
  • |Dendritic Cells/*immunology/*virology [MESH]
  • |Female [MESH]
  • |Histocompatibility Antigens Class II/analysis [MESH]
  • |Humans [MESH]
  • |Influenza A virus/*immunology [MESH]
  • |Lectins, C-Type/analysis [MESH]
  • |Monocytes/*immunology/*virology [MESH]
  • |Pregnancy [MESH]


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