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2016 ; 214
(11
): 1666-1671
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Increased Proinflammatory Responses of Monocytes and Plasmacytoid Dendritic Cells
to Influenza A Virus Infection During Pregnancy
#MMPMID27655870
Le Gars M
; Kay AW
; Bayless NL
; Aziz N
; Dekker CL
; Swan GE
; Davis MM
; Blish CA
J Infect Dis
2016[Dec]; 214
(11
): 1666-1671
PMID27655870
show ga
Pregnancy-induced alterations in immunity may contribute to the increased
morbidity associated with influenza A virus infection during pregnancy. We
characterized the immune response of monocytes and plasmacytoid dendritic cells
(pDCs) to influenza A virus infection in 21 pregnant and 21 nonpregnant women. In
pregnant women, monocytes and pDCs exhibit an exaggerated proinflammatory immune
response to 2 strains of influenza A virus, compared with nonpregnant women,
characterized by increased expression of major histocompatibility complex class
II (approximately 2.0-fold), CD69 (approximately 2.2-fold), interferon ?-induced
protein 10 (approximately 2.0-fold), and macrophage inflammatory protein 1?
(approximately 1.5-fold). This enhanced innate inflammatory response during
pregnancy could contribute to pulmonary inflammation following influenza A virus
infection.