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10.1002/bies.201600115 http://scihub22266oqcxt.onion/10.1002/bies.201600115 C5142446!5142446!27644006     free     free     free       Bioessays 2016 ; 38 (11): 1111-6 Nephropedia Template TP {{tp|p=27644006|t=2016. p53 in the Game of Transposons |pdf=|usr=}}{{27644006}} gab.com Text p53 in the Game of Transposons JO: Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=27644006 #FOAvip Throughout the animal kingdom, p53 genes function to restrain mobile elements and recent observations indicate that transposons become derepressed in human cancers. Together, these emerging lines of evidence suggest that cancers driven by p53 mutations could represent ?transpospoathies?, i.e. disease states linked to eruptions of mobile elements. The transposopathy hypothesis predicts that p53 acts through conserved mechanisms to contain transposon movement and, in this way, prevents tumor formation. How transposon eruptions provoke neoplasias is not well understood but, from a broader perspective, this hypothesis also provides an attractive framework to explore unrestrained mobile elements as inciters of late-onset idiopathic disease. Twit Text FOAVip p53 in the Game of Transposons ????Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=27644006 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27644006 #FOAvip English Wikipedia <ref>{{Cite pmid|27644006}}</ref> p53 in the Game of Transposons #MMPMID27644006 Wylie A; Jones AE; Abrams JM Bioessays 2016[Nov]; 38 (11): 1111-6 PMID27644006show ga Throughout the animal kingdom, p53 genes function to restrain mobile elements and recent observations indicate that transposons become derepressed in human cancers. Together, these emerging lines of evidence suggest that cancers driven by p53 mutations could represent ?transpospoathies?, i.e. disease states linked to eruptions of mobile elements. The transposopathy hypothesis predicts that p53 acts through conserved mechanisms to contain transposon movement and, in this way, prevents tumor formation. How transposon eruptions provoke neoplasias is not well understood but, from a broader perspective, this hypothesis also provides an attractive framework to explore unrestrained mobile elements as inciters of late-onset idiopathic disease. äp53 in the Game of Transposons (epmc).pdf DeepDyve Pubget Overpricing