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suck abstract from ncbi


10.1152/japplphysiol.00307.2016

http://scihub22266oqcxt.onion/10.1152/japplphysiol.00307.2016
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C5142255!5142255!27471237
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suck abstract from ncbi


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pmid27471237      J+Appl+Physiol+(1985) 2016 ; 121 (3): 670-7
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  • Intermittent hypoxia induces murine macrophage foam cell formation by IKK-?-dependent NF-?B pathway activation #MMPMID27471237
  • Imamura T; Poulsen O; Haddad GG
  • J Appl Physiol (1985) 2016[Sep]; 121 (3): 670-7 PMID27471237show ga
  • Intermittent hypoxia (IH)-induced inflammation increases the risk of atherosclerosis in obstructive sleep apnea (OSA) patients. However, the effect of IH on macrophage foam cell formation, a key player in atherosclerosis, has not been elucidated. We demonstrate for the first time that IH-induced foam cell formation is diminished by IKK-? deletion. Our findings highlight the importance of the IKK-?- dependent NF-?B pathway and the potential of this pathway as a therapeutic target.
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