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10.1080/2162402X.2016.1234570 http://scihub22266oqcxt.onion/10.1080/2162402X.2016.1234570 C5139626!5139626!27999749     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncoimmunology 2016 ; 5 (11): ä Nephropedia Template TP {{tp|p=27999749|t=2016. Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression |pdf=|usr=}}{{27999749}} gab.com Text Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27999749 #FOAvip Cancer cells modulate the recruitment and function of inflammatory cells to create an immunosuppressive microenvironment that favors tumor growth and metastasis. However, the tumor-derived regulatory programs that promote intratumoral immunosuppression remain poorly defined. Here, we show in a KrasLA1/+p53R172H?g/+-based mouse model that bone morphogenetic protein-4 (BMP4) augments the expression of the T cell co-inhibitory receptor ligand PD-L1 in the mesenchymal subset of lung cancer cells, leading to profound CD8+ T cell-mediated immunosuppression, producing tumor growth and metastasis. We previously reported in this model that BMP4 functions as a pro-tumorigenic factor regulated by miR-200 via GATA4/6. Thus, BMP4?mediated immunosuppression is part of a larger miR?200?directed gene expression program in tumors that promotes tumor progression, which could have important implications for cancer treatment. Twit Text FOAVip Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27999749 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27999749 #FOAvip English Wikipedia <ref>{{Cite pmid|27999749}}</ref> Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression #MMPMID27999749 Chen L; Yi X; Goswami S; Ahn YH; Roybal JD; Yang Y; Diao L; Peng D; Peng D; Fradette JJ; Wang J; Byers LA; Kurie JM; Ullrich SE; Qin FXF; Gibbons DL Oncoimmunology 2016[]; 5 (11): ä PMID27999749show ga Cancer cells modulate the recruitment and function of inflammatory cells to create an immunosuppressive microenvironment that favors tumor growth and metastasis. However, the tumor-derived regulatory programs that promote intratumoral immunosuppression remain poorly defined. Here, we show in a KrasLA1/+p53R172H?g/+-based mouse model that bone morphogenetic protein-4 (BMP4) augments the expression of the T cell co-inhibitory receptor ligand PD-L1 in the mesenchymal subset of lung cancer cells, leading to profound CD8+ T cell-mediated immunosuppression, producing tumor growth and metastasis. We previously reported in this model that BMP4 functions as a pro-tumorigenic factor regulated by miR-200 via GATA4/6. Thus, BMP4?mediated immunosuppression is part of a larger miR?200?directed gene expression program in tumors that promotes tumor progression, which could have important implications for cancer treatment. äGrowth and metastasis of lung adenocarcinoma is potentiated by BMP4-me(epmc).pdf DeepDyve Pubget Overpricing