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10.1073/pnas.1609118113

http://scihub22266oqcxt.onion/10.1073/pnas.1609118113
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C5137740!5137740!27834728
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suck abstract from ncbi


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pmid27834728      Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (48): 13827-32
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  • Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft?host interaction #MMPMID27834728
  • Mirza N; Zierhut M; Korn A; Bornemann A; Vogel W; Schmid-Horch B; Bethge WA; Stevanovi? S; Salih HR; Kanz L; Rammensee HG; Haen SP
  • Proc Natl Acad Sci U S A 2016[Nov]; 113 (48): 13827-32 PMID27834728show ga
  • As the mechanism of graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT), recognition of the recipient?s body by donor immune cells was previously believed to be based on genetic and immunological differences between donor and recipient. However, evidence in murine models and in autologous HCT has shown that also autoimmunity contributes to GVHD. In this study, we show the development of auto-reactivity after human allogeneic HCT and characterize the specific self-epitopes of T cells that may contribute to mediation of GVHD. Such autoantigens have never been characterized before. These observations contribute to a better understanding of the immune responses that are activated following hematopoietic cell transplantation.
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