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10.1073/pnas.1616574113 http://scihub22266oqcxt.onion/10.1073/pnas.1616574113 C5137732!5137732!27856754     free     free     free       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (48): 13821-6 Nephropedia Template TP {{tp|p=27856754|t=2016. Mouse model for acute Epstein?Barr virus infection |pdf=|usr=}}{{27856754}} gab.com Text Mouse model for acute Epstein Barr virus infection JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27856754 #FOAvip Epstein?Barr Virus infects human B cells and drives them into proliferation and transformation. Although more than 90% of the human population is EBV-infected, EBV-driven pathologies including B-cell lymphomas are limited by a potent T-cell immune response. Here, we present a mouse model for acute EBV infection through conditional expression of two key EBV proteins, LMP1 and LMP2A. This model reproduces EBV-driven B-cell expansion, T-cell?mediated immune surveillance of EBV-infected B cells, and fatal lymphoproliferative disease when the T-cell response is compromised as in immunosuppressed or genetically impaired patients. It thus allows one to study EBV?host interaction functionally and from an angle that should help to develop new therapies for EBV-driven hematological diseases. Twit Text FOAVip Mouse model for acute Epstein Barr virus infection ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27856754 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27856754 #FOAvip English Wikipedia <ref>{{Cite pmid|27856754}}</ref> Mouse model for acute Epstein?Barr virus infection #MMPMID27856754 Wirtz T; Weber T; Kracker S; Sommermann T; Rajewsky K; Yasuda T Proc Natl Acad Sci U S A 2016[Nov]; 113 (48): 13821-6 PMID27856754show ga Epstein?Barr Virus infects human B cells and drives them into proliferation and transformation. Although more than 90% of the human population is EBV-infected, EBV-driven pathologies including B-cell lymphomas are limited by a potent T-cell immune response. Here, we present a mouse model for acute EBV infection through conditional expression of two key EBV proteins, LMP1 and LMP2A. This model reproduces EBV-driven B-cell expansion, T-cell?mediated immune surveillance of EBV-infected B cells, and fatal lymphoproliferative disease when the T-cell response is compromised as in immunosuppressed or genetically impaired patients. It thus allows one to study EBV?host interaction functionally and from an angle that should help to develop new therapies for EBV-driven hematological diseases. äMouse model for acute Epstein?Barr virus infection (epmc).pdf DeepDyve Pubget Overpricing