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10.1073/pnas.1611380113 http://scihub22266oqcxt.onion/10.1073/pnas.1611380113 C5137702!5137702!27849593     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (48): E7808-17 Nephropedia Template TP {{tp|p=27849593|t=2016. Heparanase is required for activation and function of macrophages |pdf=|usr=}}{{27849593}} gab.com Text Heparanase is required for activation and function of macrophages JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27849593 #FOAvip The tumor microenvironment is now considered to play a major role in cancer growth and metastasis. Heparanase is the only enzyme in mammals capable of cleaving heparan sulfate, an activity that is highly implicated in tumor growth, metastasis, and inflammation. Here we provide evidence that heparanase is critically required for the activation and function of macrophages, an important constituent of the tumor microenvironment. Mechanistically, we describe a linear cascade by which heparanase activates Erk, p38, and JNK signaling in macrophages, leading to increased c-Fos levels and induction of cytokine expression in a manner that apparently does not require heparanase enzymatic activity. These results identify heparanase as a key mediator of macrophage activation and function in tumorigenesis and cross-talk with the tumor microenvironment. Twit Text FOAVip Heparanase is required for activation and function of macrophages ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27849593 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27849593 #FOAvip English Wikipedia <ref>{{Cite pmid|27849593}}</ref> Heparanase is required for activation and function of macrophages #MMPMID27849593 Gutter-Kapon L; Alishekevitz D; Shaked Y; Li JP; Aronheim A; Ilan N; Vlodavsky I Proc Natl Acad Sci U S A 2016[Nov]; 113 (48): E7808-17 PMID27849593show ga The tumor microenvironment is now considered to play a major role in cancer growth and metastasis. Heparanase is the only enzyme in mammals capable of cleaving heparan sulfate, an activity that is highly implicated in tumor growth, metastasis, and inflammation. Here we provide evidence that heparanase is critically required for the activation and function of macrophages, an important constituent of the tumor microenvironment. Mechanistically, we describe a linear cascade by which heparanase activates Erk, p38, and JNK signaling in macrophages, leading to increased c-Fos levels and induction of cytokine expression in a manner that apparently does not require heparanase enzymatic activity. These results identify heparanase as a key mediator of macrophage activation and function in tumorigenesis and cross-talk with the tumor microenvironment. äHeparanase is required for activation and function of macrophages (epmc).pdf DeepDyve Pubget Overpricing