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10.1016/j.cels.2016.10.002 http://scihub22266oqcxt.onion/10.1016/j.cels.2016.10.002 C5134923!5134923!27894998     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Syst 2016 ; 3 (5): 444-455.e2 Nephropedia Template TP {{tp|p=27894998|t=2016. Push-pull and feedback mechanisms can align signaling system outputs with inputs |pdf=|usr=}}{{27894998}} gab.com Text Push-pull and feedback mechanisms can align signaling system outputs with inputs JO: Cell Syst http://www.kidney.de/pget.php?&tw=1&pmid=27894998 #FOAvip Many cell signaling systems, including the yeast pheromone response system, exhibit ?dose-response alignment? (DoRA), in which output of one or more downstream steps closely matches the fraction of occupied receptors. DoRA can improve the fidelity of transmitted dose information. Here, we searched systematically for biochemical network topologies that produced DoRA. Most networks, including many containing feedback and feedforward loops, could not produce DoRA. However, networks including ?push-pull? mechanisms, in which the active form of a signaling species stimulates downstream activity and the nominally inactive form reduces downstream activity, enabled perfect DoRA. Networks containing feedbacks enabled DoRA, but only if they also compared feedback to input and adjusted output to match. Our results establish push-pull as a non-feedback mechanism to align output with variable input and maximize information transfer in signaling systems. They also suggest genetic approaches to determine whether particular signaling systems use feedback or push-pull control. Twit Text FOAVip Push-pull and feedback mechanisms can align signaling system outputs with inputs ????Cell Syst http://www.kidney.de/pget.php?&tw=1&pmid=27894998 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27894998 #FOAvip English Wikipedia <ref>{{Cite pmid|27894998}}</ref> Push-pull and feedback mechanisms can align signaling system outputs with inputs #MMPMID27894998 Andrews SS; Peria WJ; Yu RC; Colman-Lerner A; Brent R Cell Syst 2016[Nov]; 3 (5): 444-455.e2 PMID27894998show ga Many cell signaling systems, including the yeast pheromone response system, exhibit ?dose-response alignment? (DoRA), in which output of one or more downstream steps closely matches the fraction of occupied receptors. DoRA can improve the fidelity of transmitted dose information. Here, we searched systematically for biochemical network topologies that produced DoRA. Most networks, including many containing feedback and feedforward loops, could not produce DoRA. However, networks including ?push-pull? mechanisms, in which the active form of a signaling species stimulates downstream activity and the nominally inactive form reduces downstream activity, enabled perfect DoRA. Networks containing feedbacks enabled DoRA, but only if they also compared feedback to input and adjusted output to match. Our results establish push-pull as a non-feedback mechanism to align output with variable input and maximize information transfer in signaling systems. They also suggest genetic approaches to determine whether particular signaling systems use feedback or push-pull control. äPush-pull and feedback mechanisms can align signaling system outputs w(epmc).pdf DeepDyve Pubget Overpricing