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10.1016/j.cell.2016.10.043 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.10.043 C5131798!5131798 !27863247     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27863247 &cmd=llinks): Failed to open stream: HTTP request failed! 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A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility |pdf=|usr=}}{{27863247 }} gab.com Text A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27863247 #FOAvip Despite the accepted health benefits of consuming dietary fiber, little is known about the mechanisms by which fiber deprivation impacts the gut microbiota and alters disease risk. Using a gnotobiotic mouse model, in which animals were colonized with a synthetic human gut microbiota composed of fully sequenced commensal bacteria, we elucidated the functional interactions between dietary fiber, the gut microbiota, and the colonic mucus barrier, which serves as a primary defense against enteric pathogens. We show that during chronic or intermittent dietary fiber deficiency, the gut microbiota resorts to host-secreted mucus glycoproteins as a nutrient source, leading to erosion of the colonic mucus barrier. Dietary fiber deprivation, together with a fiber-deprived, mucus-eroding microbiota, promotes greater epithelial access and lethal colitis by the mucosal pathogen, Citrobacter rodentium. Our work reveals intricate pathways linking diet, the gut microbiome, and intestinal barrier dysfunction, which could be exploited to improve health using dietary therapeutics. Twit Text FOAVip A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27863247 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27863247 #FOAvip English Wikipedia <ref>{{Cite pmid|27863247 }}</ref> A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility #MMPMID27863247 Desai MS ; Seekatz AM ; Koropatkin NM ; Kamada N ; Hickey CA ; Wolter M ; Pudlo NA ; Kitamoto S ; Terrapon N ; Muller A ; Young VB ; Henrissat B ; Wilmes P ; Stappenbeck TS ; Núñez G ; Martens EC Cell 2016[Nov]; 167 (5 ): 1339-1353.e21 PMID27863247 show ga Despite the accepted health benefits of consuming dietary fiber, little is known about the mechanisms by which fiber deprivation impacts the gut microbiota and alters disease risk. Using a gnotobiotic mouse model, in which animals were colonized with a synthetic human gut microbiota composed of fully sequenced commensal bacteria, we elucidated the functional interactions between dietary fiber, the gut microbiota, and the colonic mucus barrier, which serves as a primary defense against enteric pathogens. We show that during chronic or intermittent dietary fiber deficiency, the gut microbiota resorts to host-secreted mucus glycoproteins as a nutrient source, leading to erosion of the colonic mucus barrier. Dietary fiber deprivation, together with a fiber-deprived, mucus-eroding microbiota, promotes greater epithelial access and lethal colitis by the mucosal pathogen, Citrobacter rodentium. Our work reveals intricate pathways linking diet, the gut microbiome, and intestinal barrier dysfunction, which could be exploited to improve health using dietary therapeutics. |*Gastrointestinal Microbiome [MESH] |Animals [MESH] |Citrobacter rodentium/physiology [MESH] |Colitis/microbiology [MESH] |Colon/microbiology [MESH] |Dietary Fiber/*administration & dosage [MESH] |Disease Susceptibility [MESH] |Enterobacteriaceae Infections/microbiology [MESH] |Escherichia coli [MESH] |Female [MESH] |Germ-Free Life [MESH] |Humans [MESH] |Intestinal Mucosa/*microbiology [MESH] |Male [MESH] |Mice [MESH]A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Bar(epmc).pdf DeepDyve Pubget Overpricing