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10.1016/j.neuron.2016.10.024

http://scihub22266oqcxt.onion/10.1016/j.neuron.2016.10.024
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suck abstract from ncbi


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pmid27883901      Neuron 2016 ; 92 (4): 687-704
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  • Tapping the brakes: cellular and synaptic mechanisms that regulate thalamic oscillations #MMPMID27883901
  • Fogerson PM; Huguenard JR
  • Neuron 2016[Nov]; 92 (4): 687-704 PMID27883901show ga
  • Thalamic oscillators contribute to both normal rhythms associated with sleep and anesthesia and abnormal, hypersynchronous oscillations that manifest behaviorally as absence seizures. In this review, we highlight new findings that refine thalamic contributions to cortical rhythms and suggest that thalamic oscillators may be subject to both local and global control. We describe endogenous thalamic mechanisms that limit network synchrony and discuss how these protective brakes might be restored to prevent absence seizures. Finally, we describe how intrinsic and circuit-level specializations among thalamocortical loops may determine their involvement in widespread oscillations and render subsets of thalamic nuclei especially vulnerable to pathological synchrony.
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