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2016 ; 311
(5
): G934-G941
Nephropedia Template TP
gab.com Text
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English Wikipedia
Neuroimmune Cross Talk in the Gut Neuroendocrine and neuroimmune pathways
contribute to the pathophysiology of irritable bowel syndrome
#MMPMID27742703
O'Malley D
Am J Physiol Gastrointest Liver Physiol
2016[Nov]; 311
(5
): G934-G941
PMID27742703
show ga
Irritable bowel syndrome (IBS) is a common disorder characterized by recurrent
abdominal pain, bloating, and disturbed bowel habit, symptoms that impact the
quality of life of sufferers. The pathophysiological changes underlying this
multifactorial condition are complex and include increased sensitivity to luminal
and mucosal factors, resulting in altered colonic transit and visceral pain.
Moreover, dysfunctional communication in the bidirectional signaling axis between
the brain and the gut, which involves efferent and afferent branches of the
peripheral nervous system, circulating endocrine hormones, and local paracrine
and neurocrine factors, including immune and perhaps even microbial signaling
molecules, has a role to play in this disorder. This minireview will examine
recent advances in our understanding of the pathophysiology of IBS and assess how
cross talk between hormones, immune, and microbe-derived factors and their
neuromodulatory effects on peripheral nerves may underlie IBS symptomatology.