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10.1152/ajplung.00272.2016 http://scihub22266oqcxt.onion/10.1152/ajplung.00272.2016 C5130533!5130533!27612965     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27612965.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Lung+Cell+Mol+Physiol 2016 ; 311 (5): L855-67 Nephropedia Template TP {{tp|p=27612965|t=2016. Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor-? ligands in a cyclooxygenase-2-dependent manner |pdf=|usr=}}{{27612965}} gab.com Text Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor- ligands in a cyclooxygenase-2-dependent manner JO: Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27612965 #FOAvip Human lung fibroblasts (HLFs) act as innate immune sentinel cells that amplify the inflammatory response to injurious stimuli. Here, we use targeted lipidomics to explore the hypothesis that HLFs also play an active role in the resolution of inflammation. We detected cyclooxygenase-2 (COX-2)-dependent production of both proinflammatory and proresolving prostaglandins (PGs) in conditioned culture medium from HLFs treated with a proinflammatory stimulus, IL-1?. Among the proresolving PGs in the HLF lipidome were several known ligands for peroxisome proliferator-activated receptor-? (PPAR?), a transcription factor whose activation in the lung yields potent anti-inflammatory, antifibrotic, and proresolving effects. Next, we used a cell-based luciferase reporter to confirm the ability of HLF supernatants to activate PPAR?, demonstrating, for the first time, that primary HLFs activated with proinflammatory IL-1? or cigarette smoke extract produce functional PPAR? ligands; this phenomenon is temporally regulated, COX-2- and lipocalin-type PGD synthase-dependent, and enhanced by arachidonic acid supplementation. Finally, we used luciferase reporter assays to show that several of the PGs in the lipidome of activated HLFs independently activate PPAR? and/or inhibit NF?B. These results indicate that HLFs, as immune sentinels, regulate both proinflammatory and proresolving responses to injurious stimuli. This novel endogenous resolution pathway represents a new therapeutic target for globally important inflammatory diseases such as chronic obstructive pulmonary disease. Twit Text FOAVip Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor- ligands in a cyclooxygenase-2-dependent manner ????Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27612965 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27612965 #FOAvip English Wikipedia <ref>{{Cite pmid|27612965}}</ref> Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor-? ligands in a cyclooxygenase-2-dependent manner #MMPMID27612965 Lacy SH; Woeller CF; Thatcher TH; Maddipati KR; Honn KV; Sime PJ; Phipps RP Am J Physiol Lung Cell Mol Physiol 2016[Nov]; 311 (5): L855-67 PMID27612965show ga Human lung fibroblasts (HLFs) act as innate immune sentinel cells that amplify the inflammatory response to injurious stimuli. Here, we use targeted lipidomics to explore the hypothesis that HLFs also play an active role in the resolution of inflammation. We detected cyclooxygenase-2 (COX-2)-dependent production of both proinflammatory and proresolving prostaglandins (PGs) in conditioned culture medium from HLFs treated with a proinflammatory stimulus, IL-1?. Among the proresolving PGs in the HLF lipidome were several known ligands for peroxisome proliferator-activated receptor-? (PPAR?), a transcription factor whose activation in the lung yields potent anti-inflammatory, antifibrotic, and proresolving effects. Next, we used a cell-based luciferase reporter to confirm the ability of HLF supernatants to activate PPAR?, demonstrating, for the first time, that primary HLFs activated with proinflammatory IL-1? or cigarette smoke extract produce functional PPAR? ligands; this phenomenon is temporally regulated, COX-2- and lipocalin-type PGD synthase-dependent, and enhanced by arachidonic acid supplementation. Finally, we used luciferase reporter assays to show that several of the PGs in the lipidome of activated HLFs independently activate PPAR? and/or inhibit NF?B. These results indicate that HLFs, as immune sentinels, regulate both proinflammatory and proresolving responses to injurious stimuli. This novel endogenous resolution pathway represents a new therapeutic target for globally important inflammatory diseases such as chronic obstructive pulmonary disease. äHuman lung fibroblasts produce proresolving peroxisome proliferator-ac(epmc).pdf DeepDyve Pubget Overpricing