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10.1152/ajprenal.00494.2016 http://scihub22266oqcxt.onion/10.1152/ajprenal.00494.2016 C5130459!5130459 !27707708     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27707708 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Renal+Physiol 2016 ; 311 (5 ): F1074-F1083 Nephropedia Template TP {{tp|p=27707708 |t=2016. Collecting duct-specific knockout of nitric oxide synthase 3 impairs water excretion in a sex-dependent manner |pdf=|usr=}}{{27707708 }} gab.com Text Collecting duct-specific knockout of nitric oxide synthase 3 impairs water excretion in a sex-dependent manner JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27707708 #FOAvip Nitric oxide (NO) inhibits collecting duct (CD) Na(+) and water reabsorption. Mice with CD-specific knockout (KO) of NO synthase 1 (NOS1) have salt-sensitive hypertension. In contrast, the role of NOS3 in CD salt and water reabsorption is unknown. Mice with CD NOS3 KO were generated with loxP-flanked exons 9-12 (encodes the calmodulin binding site) of the NOS3 gene and the aquaporin-2 promoter-Cre transgene. There were no differences between control and CD NOS3 KO mice, irrespective of sex, in food intake, water intake, urine volume, urinary Na(+) or K(+) excretion, plasma renin concentration, blood pressure, or pulse during 7 days of normal (0.3%), high (3.17%), or low (0.03%) Na(+) intake. Blood pressure was similar between genotypes during DOCA-high salt. CD NOS3 KO did not alter urine volume or urine osmolality after water deprivation. In contrast, CD NOS3 KO male, but not female, mice had lower urine volume and higher urine osmolality over the course of 7 days of water loading compared with control mice. Male, but not female, CD NOS3 KO mice had reduced urinary nitrite+nitrate excretion compared with controls after 7 days of water loading. Urine AVP and AVP-stimulated cAMP accumulation in isolated inner medullary CD were similar between genotypes. Western analysis did not reveal a significant effect of CD NOS3 KO on renal aquaporin expression. In summary, these data suggest that CD NOS3 may be involved in the diuretic response to a water load in a sex-specific manner; the mechanism of this effect remains to be determined. Twit Text FOAVip Collecting duct-specific knockout of nitric oxide synthase 3 impairs water excretion in a sex-dependent manner ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27707708 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27707708 #FOAvip English Wikipedia <ref>{{Cite pmid|27707708 }}</ref> Collecting duct-specific knockout of nitric oxide synthase 3 impairs water excretion in a sex-dependent manner #MMPMID27707708 Gao Y ; Stuart D ; Pollock JS ; Takahishi T ; Kohan DE Am J Physiol Renal Physiol 2016[Nov]; 311 (5 ): F1074-F1083 PMID27707708 show ga Nitric oxide (NO) inhibits collecting duct (CD) Na(+) and water reabsorption. Mice with CD-specific knockout (KO) of NO synthase 1 (NOS1) have salt-sensitive hypertension. In contrast, the role of NOS3 in CD salt and water reabsorption is unknown. Mice with CD NOS3 KO were generated with loxP-flanked exons 9-12 (encodes the calmodulin binding site) of the NOS3 gene and the aquaporin-2 promoter-Cre transgene. There were no differences between control and CD NOS3 KO mice, irrespective of sex, in food intake, water intake, urine volume, urinary Na(+) or K(+) excretion, plasma renin concentration, blood pressure, or pulse during 7 days of normal (0.3%), high (3.17%), or low (0.03%) Na(+) intake. Blood pressure was similar between genotypes during DOCA-high salt. CD NOS3 KO did not alter urine volume or urine osmolality after water deprivation. In contrast, CD NOS3 KO male, but not female, mice had lower urine volume and higher urine osmolality over the course of 7 days of water loading compared with control mice. Male, but not female, CD NOS3 KO mice had reduced urinary nitrite+nitrate excretion compared with controls after 7 days of water loading. Urine AVP and AVP-stimulated cAMP accumulation in isolated inner medullary CD were similar between genotypes. Western analysis did not reveal a significant effect of CD NOS3 KO on renal aquaporin expression. In summary, these data suggest that CD NOS3 may be involved in the diuretic response to a water load in a sex-specific manner; the mechanism of this effect remains to be determined. |Animals [MESH] |Blood Pressure/physiology [MESH] |Drinking/physiology [MESH] |Eating/physiology [MESH] |Female [MESH] |Kidney Tubules, Collecting/*metabolism [MESH] |Kidney/metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Nitric Oxide Synthase Type III/*genetics/metabolism [MESH] |Osmolar Concentration [MESH] |Renin/blood [MESH] |Sex Factors [MESH]Collecting duct-specific knockout of nitric oxide synthase 3 impairs w(epmc).pdf DeepDyve Pubget Overpricing