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10.1080/21541248.2016.1213781 http://scihub22266oqcxt.onion/10.1080/21541248.2016.1213781 C5129893!5129893!27427966     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Small+GTPases 2016 ; 7 (4): 252-6 Nephropedia Template TP {{tp|p=27427966|t=2016. Regulation of membrane traffic by Rab GEF and GAP cascades |pdf=|usr=}}{{27427966}} gab.com Text Regulation of membrane traffic by Rab GEF and GAP cascades JO: Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=27427966 #FOAvip Rab GTPases serve as master regulators of membrane traffic, each typically controlling several different aspects of a specific stage of membrane traffic by recruiting diverse effector proteins such as cytoskeletal motors, vesicle tethering proteins and regulators of SNARE complex assembly. Rabs, in turn, are regulated by specific guanine nucleotide exchange factors (GEFs), which catalyze the displacement of GDP and binding of GTP, as well as GTPase activating proteins (GAPs) that stimulate the slow intrinsic rate of GTP hydrolysis. Here I review our studies on the final stages of the yeast secretory pathway that have led us to propose that adjacent Rabs on a pathway are networked to one another through their regulators; specifically we have shown that the Rab, Ypt32, in its GTP-bound form recruits both Sec2, the GEF that activates the downstream Rab, Sec4, as well as Gyp1, the GAP that inactivates the upstream Rab, Ypt1. The postulated effect of these counter-current cascades is a programmed series of abrupt Rab transitions that lead to critical changes in the functional identity of the membrane as it flows along the exocytic pathway. Phosphoinositides also play key roles in the temporal and spatial regulation of membrane traffic. The Golgi pool of phosphatidylinositol 4-phosphate (PI(4)P) works in concert with Ypt32 to initially recruit Sec2, yet a subsequent drop in PI(4)P levels directs a regulatory switch in Sec2 function in which it binds to the Sec4 effector Sec15 generating a positive feedback loop. PI(4)P distribution together with Sec2 phosphorylation by a casein kinase determines when and where each regulatory circuit is used. Twit Text FOAVip Regulation of membrane traffic by Rab GEF and GAP cascades ????Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=27427966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27427966 #FOAvip English Wikipedia <ref>{{Cite pmid|27427966}}</ref> Regulation of membrane traffic by Rab GEF and GAP cascades #MMPMID27427966 Novick P Small GTPases 2016[Oct]; 7 (4): 252-6 PMID27427966show ga Rab GTPases serve as master regulators of membrane traffic, each typically controlling several different aspects of a specific stage of membrane traffic by recruiting diverse effector proteins such as cytoskeletal motors, vesicle tethering proteins and regulators of SNARE complex assembly. Rabs, in turn, are regulated by specific guanine nucleotide exchange factors (GEFs), which catalyze the displacement of GDP and binding of GTP, as well as GTPase activating proteins (GAPs) that stimulate the slow intrinsic rate of GTP hydrolysis. Here I review our studies on the final stages of the yeast secretory pathway that have led us to propose that adjacent Rabs on a pathway are networked to one another through their regulators; specifically we have shown that the Rab, Ypt32, in its GTP-bound form recruits both Sec2, the GEF that activates the downstream Rab, Sec4, as well as Gyp1, the GAP that inactivates the upstream Rab, Ypt1. The postulated effect of these counter-current cascades is a programmed series of abrupt Rab transitions that lead to critical changes in the functional identity of the membrane as it flows along the exocytic pathway. Phosphoinositides also play key roles in the temporal and spatial regulation of membrane traffic. The Golgi pool of phosphatidylinositol 4-phosphate (PI(4)P) works in concert with Ypt32 to initially recruit Sec2, yet a subsequent drop in PI(4)P levels directs a regulatory switch in Sec2 function in which it binds to the Sec4 effector Sec15 generating a positive feedback loop. PI(4)P distribution together with Sec2 phosphorylation by a casein kinase determines when and where each regulatory circuit is used. äRegulation of membrane traffic by Rab GEF and GAP cascades (epmc).pdf DeepDyve Pubget Overpricing