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10.1038/ncb3439 http://scihub22266oqcxt.onion/10.1038/ncb3439 C5129868!5129868!27842058     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2016 ; 18 (12): 1302-10 Nephropedia Template TP {{tp|p=27842058|t=2016. Developmentally programmed germ cell remodeling by endodermal cell cannibalism |pdf=|usr=}}{{27842058}} gab.com Text Developmentally programmed germ cell remodeling by endodermal cell cannibalism JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27842058 #FOAvip Primordial germ cells (PGCs) in many species associate intimately with endodermal cells, bu the significance of such interactions is largely unexplored. Here, we show that C. elegans PGCs form lobes that are removed and digested by endodermal cells, dramatically altering PGC size and mitochondrial content. We demonstrate that endodermal cells do not scavenge lobes PGCs shed, but rather, actively remove lobes from the cell body. CED-10/Rac1-induced actin, DYN-1/dynamin, and LST-4/SNX9 transiently surround lobe necks and are required within endodermal cells for lobe scission, suggesting that scission occurs through a mechanism resembling vesicle endocytosis. These findings reveal an unexpected role for endoderm in altering the contents of embryonic PGCs, and define a form of developmentally programmed cell remodeling involving intercellular cannibalism. Active roles for engulfing cells have been proposed in several neuronal remodeling events, suggesting that intercellular cannibalism may be a more widespread method used to shape cells. Twit Text FOAVip Developmentally programmed germ cell remodeling by endodermal cell cannibalism ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27842058 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27842058 #FOAvip English Wikipedia <ref>{{Cite pmid|27842058}}</ref> Developmentally programmed germ cell remodeling by endodermal cell cannibalism #MMPMID27842058 Abdu Y; Maniscalco C; Heddleston JM; Chew TL; Nance J Nat Cell Biol 2016[Dec]; 18 (12): 1302-10 PMID27842058show ga Primordial germ cells (PGCs) in many species associate intimately with endodermal cells, bu the significance of such interactions is largely unexplored. Here, we show that C. elegans PGCs form lobes that are removed and digested by endodermal cells, dramatically altering PGC size and mitochondrial content. We demonstrate that endodermal cells do not scavenge lobes PGCs shed, but rather, actively remove lobes from the cell body. CED-10/Rac1-induced actin, DYN-1/dynamin, and LST-4/SNX9 transiently surround lobe necks and are required within endodermal cells for lobe scission, suggesting that scission occurs through a mechanism resembling vesicle endocytosis. These findings reveal an unexpected role for endoderm in altering the contents of embryonic PGCs, and define a form of developmentally programmed cell remodeling involving intercellular cannibalism. Active roles for engulfing cells have been proposed in several neuronal remodeling events, suggesting that intercellular cannibalism may be a more widespread method used to shape cells. äDevelopmentally programmed germ cell remodeling by endodermal cell can(epmc).pdf DeepDyve Pubget Overpricing