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10.1002/eji.201646359 http://scihub22266oqcxt.onion/10.1002/eji.201646359 C5129535!5129535!27592607     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2016 ; 46 (11): 2659-68 Nephropedia Template TP {{tp|p=27592607|t=2016. Plasmacytoid dendritic cells induce tolerance predominantly by cargoing antigen to lymph nodes |pdf=|usr=}}{{27592607}} gab.com Text Plasmacytoid dendritic cells induce tolerance predominantly by cargoing antigen to lymph nodes JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27592607 #FOAvip Plasmacytoid dendritic cells (pDCs) have been shown to induce tolerance to innocuous antigens. Their migratory properties allow them to take up antigens from the periphery and transport them to the draining lymph nodes or to the thymus. However, pDC?T?cell interaction in the primary and secondary lymphoid organs still remains poorly defined. In this study, we show that resting pDCs loaded with exogenous antigen could induce tolerance when transferred intralymphatically into a single lymph node of wild?type C57BL/6 mice. However, this was a result of antigen transfer from pDCs to endogenous antigen presenting cells and subsequent abortive proliferation of cognate CD4+ T cells. pDCs could not directly induce the proliferation of CD4+ T cells, as observed in mice lacking MHC class II gene. Moreover, pDCs failed to make physical contacts with OT?II cells as revealed by two?photon imaging. Thus, the role of resting pDCs in tolerance induction seems to be independent of its direct interaction with cognate CD4+ T cells. Twit Text FOAVip Plasmacytoid dendritic cells induce tolerance predominantly by cargoing antigen to lymph nodes ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27592607 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27592607 #FOAvip English Wikipedia <ref>{{Cite pmid|27592607}}</ref> Plasmacytoid dendritic cells induce tolerance predominantly by cargoing antigen to lymph nodes #MMPMID27592607 Kohli K; Janssen A; Förster R Eur J Immunol 2016[Nov]; 46 (11): 2659-68 PMID27592607show ga Plasmacytoid dendritic cells (pDCs) have been shown to induce tolerance to innocuous antigens. Their migratory properties allow them to take up antigens from the periphery and transport them to the draining lymph nodes or to the thymus. However, pDC?T?cell interaction in the primary and secondary lymphoid organs still remains poorly defined. In this study, we show that resting pDCs loaded with exogenous antigen could induce tolerance when transferred intralymphatically into a single lymph node of wild?type C57BL/6 mice. However, this was a result of antigen transfer from pDCs to endogenous antigen presenting cells and subsequent abortive proliferation of cognate CD4+ T cells. pDCs could not directly induce the proliferation of CD4+ T cells, as observed in mice lacking MHC class II gene. Moreover, pDCs failed to make physical contacts with OT?II cells as revealed by two?photon imaging. Thus, the role of resting pDCs in tolerance induction seems to be independent of its direct interaction with cognate CD4+ T cells. äPlasmacytoid dendritic cells induce tolerance predominantly by cargoin(epmc).pdf DeepDyve Pubget Overpricing