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10.1172/JCI90425 http://scihub22266oqcxt.onion/10.1172/JCI90425 C5127672!5127672!27841756     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27841756&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest ä ; 126 (12): 4654-8 Nephropedia Template TP {{tp|p=27841756|t=ä. Hemoglobin S-nitrosylation plays an essential role in cardioprotection |pdf=|usr=}}{{27841756}} gab.com Text Hemoglobin S-nitrosylation plays an essential role in cardioprotection JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27841756 #FOAvip Homeostatic control of tissue oxygenation is achieved largely through changes in blood flow that are regulated by the classic physiological response of hypoxic vasodilation. The role of nitric oxide (NO) in the control of blood flow is a central tenet of cardiovascular biology. However, extensive evidence now indicates that hypoxic vasodilation entails S-nitrosothiol?based (SNO-based) vasoactivity (rather than NO per se) and that this activity is conveyed substantially by the ?Cys93 residue in hemoglobin. Thus, tissue oxygenation in the respiratory cycle is dependent on S-nitrosohemoglobin. This perspective predicts that red blood cells (RBCs) may play an important but previously undescribed role in cardioprotection. Here, we have found that cardiac injury and mortality in models of myocardial infarction and heart failure were greatly enhanced in mice lacking ?Cys93 S-nitrosylation. In addition, ?Cys93 mutant mice exhibited adaptive collateralization of cardiac vasculature that mitigated ischemic injury and predicted outcomes after myocardial infarction. Enhanced myopathic injury and mortality across different etiologies in the absence of ?Cys93 confirm the central cardiovascular role of RBC-derived SNO-based vasoactivity and point to a potential locus of therapeutic intervention. Our findings also suggest the possibility that RBCs may play a previously unappreciated role in heart disease. Twit Text FOAVip Hemoglobin S-nitrosylation plays an essential role in cardioprotection ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27841756 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27841756 #FOAvip English Wikipedia <ref>{{Cite pmid|27841756}}</ref> Hemoglobin S-nitrosylation plays an essential role in cardioprotection #MMPMID27841756 Zhang R; Hess DT; Reynolds JD; Stamler JS J Clin Invest ä[]; 126 (12): 4654-8 PMID27841756show ga Homeostatic control of tissue oxygenation is achieved largely through changes in blood flow that are regulated by the classic physiological response of hypoxic vasodilation. The role of nitric oxide (NO) in the control of blood flow is a central tenet of cardiovascular biology. However, extensive evidence now indicates that hypoxic vasodilation entails S-nitrosothiol?based (SNO-based) vasoactivity (rather than NO per se) and that this activity is conveyed substantially by the ?Cys93 residue in hemoglobin. Thus, tissue oxygenation in the respiratory cycle is dependent on S-nitrosohemoglobin. This perspective predicts that red blood cells (RBCs) may play an important but previously undescribed role in cardioprotection. Here, we have found that cardiac injury and mortality in models of myocardial infarction and heart failure were greatly enhanced in mice lacking ?Cys93 S-nitrosylation. In addition, ?Cys93 mutant mice exhibited adaptive collateralization of cardiac vasculature that mitigated ischemic injury and predicted outcomes after myocardial infarction. Enhanced myopathic injury and mortality across different etiologies in the absence of ?Cys93 confirm the central cardiovascular role of RBC-derived SNO-based vasoactivity and point to a potential locus of therapeutic intervention. Our findings also suggest the possibility that RBCs may play a previously unappreciated role in heart disease. äHemoglobin S-nitrosylation plays an essential role in cardioprotection(epmc).pdf DeepDyve Pubget Overpricing