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10.1073/pnas.1608767113 http://scihub22266oqcxt.onion/10.1073/pnas.1608767113 C5127353!5127353!27821730     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (47): E7500-9 Nephropedia Template TP {{tp|p=27821730|t=2016. Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks |pdf=|usr=}}{{27821730}} gab.com Text Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27821730 #FOAvip Cells directionally migrate in response to a variety of external cues, including chemical, electrical, and mechanical stimuli; however, only response to chemoattractants has been characterized at the molecular level. Binding of chemoattractants to specific surface receptors triggers rapid, transient activation of many signal transduction and cytoskeletal events. We discovered that brief application of shear stress to cells likely elicits activation of all of the same events. Responses to chemoattractants and shear stress are susceptible to many of the same perturbations, although that to mechanical stimulation uniquely is blocked by disruption of the actin cytoskeleton. Our finding provides insight into the molecular mechanism of cellular response to mechanical stimuli and has important implications for integration of chemical and mechanical inputs. Twit Text FOAVip Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27821730 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27821730 #FOAvip English Wikipedia <ref>{{Cite pmid|27821730}}</ref> Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks #MMPMID27821730 Artemenko Y; Axiotakis L; Borleis J; Iglesias PA; Devreotes PN Proc Natl Acad Sci U S A 2016[Nov]; 113 (47): E7500-9 PMID27821730show ga Cells directionally migrate in response to a variety of external cues, including chemical, electrical, and mechanical stimuli; however, only response to chemoattractants has been characterized at the molecular level. Binding of chemoattractants to specific surface receptors triggers rapid, transient activation of many signal transduction and cytoskeletal events. We discovered that brief application of shear stress to cells likely elicits activation of all of the same events. Responses to chemoattractants and shear stress are susceptible to many of the same perturbations, although that to mechanical stimulation uniquely is blocked by disruption of the actin cytoskeleton. Our finding provides insight into the molecular mechanism of cellular response to mechanical stimuli and has important implications for integration of chemical and mechanical inputs. äChemical and mechanical stimuli act on common signal transduction and (epmc).pdf DeepDyve Pubget Overpricing