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10.1073/pnas.1610342113 http://scihub22266oqcxt.onion/10.1073/pnas.1610342113 C5127341!5127341!27821764     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (47): 13498-503 Nephropedia Template TP {{tp|p=27821764|t=2016. The cholinergic forebrain arousal system acts directly on the circadian pacemaker |pdf=|usr=}}{{27821764}} gab.com Text The cholinergic forebrain arousal system acts directly on the circadian pacemaker JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27821764 #FOAvip Sleep and wake states are regulated by a variety of mechanisms. One such important system is the circadian clock, which provides temporal structure to sleep and wake. Conversely, changes in behavioral state can influence the phase of the circadian clock. Here we demonstrate that the level of wakefulness is critical for arousal to reset circadian clock phase. We then show that treatments that produce arousal and reset the circadian clock activate the basal forebrain. Finally, we demonstrate that cholinergic input from the basal forebrain is both necessary and sufficient for eliciting this arousal-induced resetting of the circadian clock. These results establish a functional link between the major forebrain arousal center and the circadian system. Twit Text FOAVip The cholinergic forebrain arousal system acts directly on the circadian pacemaker ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27821764 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27821764 #FOAvip English Wikipedia <ref>{{Cite pmid|27821764}}</ref> The cholinergic forebrain arousal system acts directly on the circadian pacemaker #MMPMID27821764 Yamakawa GR; Basu P; Cortese F; MacDonnell J; Whalley D; Smith VM; Antle MC Proc Natl Acad Sci U S A 2016[Nov]; 113 (47): 13498-503 PMID27821764show ga Sleep and wake states are regulated by a variety of mechanisms. One such important system is the circadian clock, which provides temporal structure to sleep and wake. Conversely, changes in behavioral state can influence the phase of the circadian clock. Here we demonstrate that the level of wakefulness is critical for arousal to reset circadian clock phase. We then show that treatments that produce arousal and reset the circadian clock activate the basal forebrain. Finally, we demonstrate that cholinergic input from the basal forebrain is both necessary and sufficient for eliciting this arousal-induced resetting of the circadian clock. These results establish a functional link between the major forebrain arousal center and the circadian system. äThe cholinergic forebrain arousal system acts directly on the circadia(epmc).pdf DeepDyve Pubget Overpricing