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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (47): 13318-23 Nephropedia Template TP
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One low-dose exposure of gold nanoparticles induces long-term changes in human cells #MMPMID27821760
Falagan-Lotsch P; Grzincic EM; Murphy CJ
Proc Natl Acad Sci U S A 2016[Nov]; 113 (47): 13318-23 PMID27821760show ga
Gold nanoparticles are promising candidates for optical sensing, bioimaging, delivery, and therapeutic applications due to their size- and shape-dependent physical properties and inherent biocompatibility compared with other metallic nanoparticles. Many studies have found that these particles are generally nontoxic at low doses for most, but not all, initial surface treatments. In this study, a long-term (20 wk) exposure of a set of gold nanoparticles to a human cell line was performed in two ways: an acute burst of nanoparticle exposure compared with a continuous, chronic exposure at the same concentration. Overall, it was found that an acute burst of exposure is more harmful to cells, and that cells can adapt to long-term nanoparticle exposure.