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10.1073/pnas.1611024113 http://scihub22266oqcxt.onion/10.1073/pnas.1611024113 C5127317!5127317!27821733     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (47): E7464-73 Nephropedia Template TP {{tp|p=27821733|t=2016. A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis |pdf=|usr=}}{{27821733}} gab.com Text A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27821733 #FOAvip Macropinocytosis and phagocytosis are two Ras-regulated, highly related processes of great physiological relevance collectively termed large-scale endocytosis. Both are actin-driven and entail engulfment of extracellular material by crown-like protrusions. Aside from the Arp2/3 complex, which serves as the main nucleator of branched actin filaments at the cup rim, the underlying mechanisms of actin assembly still remain elusive. Here, we analyzed the role of Diaphanous-related formin G (ForG) from Dictyostelium by biochemical, genetic, and imaging techniques. Our data demonstrate that this formin exhibits a rather weak nucleation activity and imply that ForG-mediated filament elongation synergizes with the Arp2/3 complex in actin assembly. Finally, we identify ForG as a Ras-regulated formin and show its significance for actin assembly in endocytic structures. Twit Text FOAVip A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27821733 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27821733 #FOAvip English Wikipedia <ref>{{Cite pmid|27821733}}</ref> A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis #MMPMID27821733 Junemann A; Fili? V; Winterhoff M; Nordholz B; Litschko C; Schwellenbach H; Stephan T; Weber I; Faix J Proc Natl Acad Sci U S A 2016[Nov]; 113 (47): E7464-73 PMID27821733show ga Macropinocytosis and phagocytosis are two Ras-regulated, highly related processes of great physiological relevance collectively termed large-scale endocytosis. Both are actin-driven and entail engulfment of extracellular material by crown-like protrusions. Aside from the Arp2/3 complex, which serves as the main nucleator of branched actin filaments at the cup rim, the underlying mechanisms of actin assembly still remain elusive. Here, we analyzed the role of Diaphanous-related formin G (ForG) from Dictyostelium by biochemical, genetic, and imaging techniques. Our data demonstrate that this formin exhibits a rather weak nucleation activity and imply that ForG-mediated filament elongation synergizes with the Arp2/3 complex in actin assembly. Finally, we identify ForG as a Ras-regulated formin and show its significance for actin assembly in endocytic structures. äA Diaphanous-related formin links Ras signaling directly to actin asse(epmc).pdf DeepDyve Pubget Overpricing