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10.1038/ncb3106 http://scihub22266oqcxt.onion/10.1038/ncb3106 C5126975!5126975 !25706235     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25706235 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Cell+Biol 2015 ; 17 (3 ): 241-50 Nephropedia Template TP {{tp|p=25706235 |t=2015. Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs |pdf=|usr=}}{{25706235 }} gab.com Text Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25706235 #FOAvip Epithelial organs develop through tightly coordinated events of cell proliferation and differentiation in which endocytosis plays a major role. Despite recent advances, how endocytosis regulates the development of vertebrate organs is still unknown. Here we describe a mechanism that facilitates the apical availability of endosomal SNARE receptors for epithelial morphogenesis through the developmental upregulation of plasmolipin (pllp) in a highly endocytic segment of the zebrafish posterior midgut. The protein PLLP (Pllp in fish) recruits the clathrin adaptor EpsinR to sort the SNARE machinery of the endolysosomal pathway into the subapical compartment, which is a switch for polarized endocytosis. Furthermore, PLLP expression induces apical Crumbs internalization and the activation of the Notch signalling pathway, both crucial steps in the acquisition of cell polarity and differentiation of epithelial cells. We thus postulate that differential apical endosomal SNARE sorting is a mechanism that regulates epithelial patterning. Twit Text FOAVip Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25706235 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25706235 #FOAvip English Wikipedia <ref>{{Cite pmid|25706235 }}</ref> Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs #MMPMID25706235 Rodríguez-Fraticelli AE ; Bagwell J ; Bosch-Fortea M ; Boncompain G ; Reglero-Real N ; García-León MJ ; Andrés G ; Toribio ML ; Alonso MA ; Millán J ; Perez F ; Bagnat M ; Martín-Belmonte F Nat Cell Biol 2015[Mar]; 17 (3 ): 241-50 PMID25706235 show ga Epithelial organs develop through tightly coordinated events of cell proliferation and differentiation in which endocytosis plays a major role. Despite recent advances, how endocytosis regulates the development of vertebrate organs is still unknown. Here we describe a mechanism that facilitates the apical availability of endosomal SNARE receptors for epithelial morphogenesis through the developmental upregulation of plasmolipin (pllp) in a highly endocytic segment of the zebrafish posterior midgut. The protein PLLP (Pllp in fish) recruits the clathrin adaptor EpsinR to sort the SNARE machinery of the endolysosomal pathway into the subapical compartment, which is a switch for polarized endocytosis. Furthermore, PLLP expression induces apical Crumbs internalization and the activation of the Notch signalling pathway, both crucial steps in the acquisition of cell polarity and differentiation of epithelial cells. We thus postulate that differential apical endosomal SNARE sorting is a mechanism that regulates epithelial patterning. |*Gene Expression Regulation, Developmental [MESH] |Adaptor Proteins, Vesicular Transport/genetics/metabolism [MESH] |Animals [MESH] |Cell Differentiation [MESH] |Cell Line [MESH] |Cell Polarity [MESH] |Cell Proliferation [MESH] |Embryo, Nonmammalian [MESH] |Endocytosis [MESH] |Endosomes/*metabolism/ultrastructure [MESH] |Epithelial Cells/*metabolism/ultrastructure [MESH] |Epithelium/*metabolism/ultrastructure [MESH] |Kidney Tubules/metabolism/ultrastructure [MESH] |Lysosomes/*metabolism/ultrastructure [MESH] |Mice [MESH] |Myelin and Lymphocyte-Associated Proteolipid Proteins/genetics/metabolism [MESH] |Nerve Tissue Proteins/genetics/metabolism [MESH] |Receptors, Notch/genetics/metabolism [MESH] |SNARE Proteins/genetics/metabolism [MESH] |Signal Transduction [MESH]Developmental regulation of apical endocytosis controls epithelial pat(epmc).pdf DeepDyve Pubget Overpricing