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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Case+Rep+Nephrol+Dial 2016 ; 6 (3): 133-42 Nephropedia Template TP
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Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis #MMPMID27904866
Yabuuchi J; Suwabe T; Ueno T; Hoshino J; Sekine A; Hayami N; Oguro M; Kunisawa K; Kawada M; Yamanouchi M; Sumida K; Mizuno H; Hasegawa E; Sawa N; Takaichi K; Ohashi K; Fujii T; Ubara Y
Case Rep Nephrol Dial 2016[Sep]; 6 (3): 133-42 PMID27904866show ga
We report a case of glomerulopathy in a 36-year-old Japanese woman with primary Sjögren syndrome (pSS). The first renal biopsy suggested membranous glomerulonephritis. However, repeat biopsy was performed after 16 years because of increased proteinuria, revealing membranoproliferative glomerulonephritis with mesangial deposits, subendothelial deposits, and subepithelial deposits. Immunofluorescent studies showed predominant deposition of IgG2 and IgG4. This patient was positive for antinuclear antibody and anti-SS-A antibody. Sicca syndrome was confirmed by a positive Schirmer test and positive Rose Bengal test. Therefore, pSS-related glomerulopathy was considered to be the most likely diagnosis.