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2016 ; 6
(3
): 133-142
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English Wikipedia
Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to
Membranoproliferative Glomerulonephritis
#MMPMID27904866
Yabuuchi J
; Suwabe T
; Ueno T
; Hoshino J
; Sekine A
; Hayami N
; Oguro M
; Kunisawa K
; Kawada M
; Yamanouchi M
; Sumida K
; Mizuno H
; Hasegawa E
; Sawa N
; Takaichi K
; Ohashi K
; Fujii T
; Ubara Y
Case Rep Nephrol Dial
2016[Sep]; 6
(3
): 133-142
PMID27904866
show ga
We report a case of glomerulopathy in a 36-year-old Japanese woman with primary
Sjögren syndrome (pSS). The first renal biopsy suggested membranous
glomerulonephritis. However, repeat biopsy was performed after 16 years because
of increased proteinuria, revealing membranoproliferative glomerulonephritis with
mesangial deposits, subendothelial deposits, and subepithelial deposits.
Immunofluorescent studies showed predominant deposition of IgG2 and IgG4. This
patient was positive for antinuclear antibody and anti-SS-A antibody. Sicca
syndrome was confirmed by a positive Schirmer test and positive Rose Bengal test.
Therefore, pSS-related glomerulopathy was considered to be the most likely
diagnosis.