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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Arthritis+Rheumatol
2016 ; 68
(2
): 282-98
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
American College of Rheumatology/Spondylitis Association of
America/Spondyloarthritis Research and Treatment Network 2015 Recommendations for
the Treatment of Ankylosing Spondylitis and Nonradiographic Axial
Spondyloarthritis
#MMPMID26401991
Ward MM
; Deodhar A
; Akl EA
; Lui A
; Ermann J
; Gensler LS
; Smith JA
; Borenstein D
; Hiratzka J
; Weiss PF
; Inman RD
; Majithia V
; Haroon N
; Maksymowych WP
; Joyce J
; Clark BM
; Colbert RA
; Figgie MP
; Hallegua DS
; Prete PE
; Rosenbaum JT
; Stebulis JA
; van den Bosch F
; Yu DT
; Miller AS
; Reveille JD
; Caplan L
Arthritis Rheumatol
2016[Feb]; 68
(2
): 282-98
PMID26401991
show ga
OBJECTIVE: To provide evidence-based recommendations for the treatment of
patients with ankylosing spondylitis (AS) and nonradiographic axial
spondyloarthritis (SpA). METHODS: A core group led the development of the
recommendations, starting with the treatment questions. A literature review group
conducted systematic literature reviews of studies that addressed 57 specific
treatment questions, based on searches conducted in OVID Medline (1946-2014),
PubMed (1966-2014), and the Cochrane Library. We assessed the quality of evidence
using the Grading of Recommendations, Assessment, Development and Evaluation
(GRADE) method. A separate voting group reviewed the evidence and voted on
recommendations for each question using the GRADE framework. RESULTS: In patients
with active AS, the strong recommendations included use of nonsteroidal
antiinflammatory drugs (NSAIDs), use of tumor necrosis factor inhibitors (TNFi)
when activity persists despite NSAID treatment, not to use systemic
glucocorticoids, use of physical therapy, and use of hip arthroplasty for
patients with advanced hip arthritis. Among the conditional recommendations was
that no particular TNFi was preferred except in patients with concomitant
inflammatory bowel disease or recurrent iritis, in whom TNFi monoclonal
antibodies should be used. In patients with active nonradiographic axial SpA
despite treatment with NSAIDs, we conditionally recommend treatment with TNFi.
Other recommendations for patients with nonradiographic axial SpA were based on
indirect evidence and were the same as for patients with AS. CONCLUSION: These
recommendations provide guidance for the management of common clinical questions
in AS and nonradiographic axial SpA. Additional research on optimal medication
management over time, disease monitoring, and preventive care is needed to help
establish best practices in these areas.
|*Arthroplasty, Replacement, Hip
[MESH]
|*Physical Therapy Modalities
[MESH]
|Adalimumab/therapeutic use
[MESH]
|Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
[MESH]