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10.4049/jimmunol.1600993 http://scihub22266oqcxt.onion/10.4049/jimmunol.1600993 C5123812!5123812!27794001     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 197 (11): 4351-9 Nephropedia Template TP {{tp|p=27794001|t=2016. IL-18 and subcapsular lymph node macrophages are essential for enhanced B cell responses with TLR4 agonist adjuvants|| |pdf=|usr=}}{{27794001}} gab.com Text IL-18 and subcapsular lymph node macrophages are essential for enhanced B cell responses with TLR4 agonist adjuvants|| JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27794001 #FOAvip Designing modern vaccine adjuvants depends on understanding the cellular and molecular events that connect innate and adaptive immune responses. The synthetic TLR4 agonist GLA formulated in a stable emulsion (GLA-SE) augments both cellular and humoral immune responses to vaccine antigens. This adjuvant is currently included in several vaccines undergoing clinical evaluation including those for tuberculosis, leishmaniasis, and influenza. Delineation of the mechanisms of adjuvant activity will enable more informative evaluation of clinical trials. Early after injection, GLA-SE induces substantially more antigen-specific B cells, higher serum antibody titers and greater numbers of T follicular helper (TFH) and TH1 cells than alum, the squalene-in-water emulsion (SE) alone, or GLA without SE. GLA-SE augments antigen-specific B cell differentiation into germinal center and memory precursor B cells as well as pre-plasmablasts that rapidly secrete antibodies. CD169+ SIGNR1+ subcapsular medullary macrophages are the primary cells to take up GLA-SE after immunization and are critical for the innate immune responses, including rapid IL-18 production, induced by GLA-SE. Depletion of subcapsular macrophages (SCM?) or abrogation of IL-18 signaling dramatically impairs the antigen-specific B cell and antibody responses augmented by GLA-SE. Depletion of SCM? also drastically reduces the TH1 but not TFH response. Thus the GLA-SE adjuvant operates through interaction with IL-18-producing SCM? for the rapid induction of B cell expansion and differentiation, antibody secretion and TH1 responses, whereas augmentation of TFH numbers by GLA-SE is independent of SCM?. Twit Text FOAVip IL-18 and subcapsular lymph node macrophages are essential for enhanced B cell responses with TLR4 agonist adjuvants|| ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27794001 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27794001 #FOAvip English Wikipedia <ref>{{Cite pmid|27794001}}</ref> IL-18 and subcapsular lymph node macrophages are essential for enhanced B cell responses with TLR4 agonist adjuvants|| #MMPMID27794001 Desbien AL; Cauwelaert ND; Reed SJ; Bailor HR; Liang H; Carter D; Duthie MS; Fox CB; Reed SG; Orr MT J Immunol 2016[Dec]; 197 (11): 4351-9 PMID27794001show ga Designing modern vaccine adjuvants depends on understanding the cellular and molecular events that connect innate and adaptive immune responses. The synthetic TLR4 agonist GLA formulated in a stable emulsion (GLA-SE) augments both cellular and humoral immune responses to vaccine antigens. This adjuvant is currently included in several vaccines undergoing clinical evaluation including those for tuberculosis, leishmaniasis, and influenza. Delineation of the mechanisms of adjuvant activity will enable more informative evaluation of clinical trials. Early after injection, GLA-SE induces substantially more antigen-specific B cells, higher serum antibody titers and greater numbers of T follicular helper (TFH) and TH1 cells than alum, the squalene-in-water emulsion (SE) alone, or GLA without SE. GLA-SE augments antigen-specific B cell differentiation into germinal center and memory precursor B cells as well as pre-plasmablasts that rapidly secrete antibodies. CD169+ SIGNR1+ subcapsular medullary macrophages are the primary cells to take up GLA-SE after immunization and are critical for the innate immune responses, including rapid IL-18 production, induced by GLA-SE. Depletion of subcapsular macrophages (SCM?) or abrogation of IL-18 signaling dramatically impairs the antigen-specific B cell and antibody responses augmented by GLA-SE. Depletion of SCM? also drastically reduces the TH1 but not TFH response. Thus the GLA-SE adjuvant operates through interaction with IL-18-producing SCM? for the rapid induction of B cell expansion and differentiation, antibody secretion and TH1 responses, whereas augmentation of TFH numbers by GLA-SE is independent of SCM?. äIL-18 and subcapsular lymph node macrophages are essential for enhance(epmc).pdf DeepDyve Pubget Overpricing