Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.molcel.2016.09.013 http://scihub22266oqcxt.onion/10.1016/j.molcel.2016.09.013 C5123764!5123764!27746021     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2016 ; 64 (3): 549-64 Nephropedia Template TP {{tp|p=27746021|t=2016. Direct regulation of alternative splicing by SMAD3 through PCBP1 is essential to the tumor-promoting role of TGF-? |pdf=|usr=}}{{27746021}} gab.com Text Direct regulation of alternative splicing by SMAD3 through PCBP1 is essential to the tumor-promoting role of TGF- JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=27746021 #FOAvip In advanced stages of cancers, TGF-? promotes tumor progression in conjunction with inputs from receptor tyrosine kinase pathways. However, mechanisms that underpin the signaling cooperation and convert TGF-? from a potent growth inhibitor to a tumor promoter are not fully understood. We report here that TGF-? directly regulates alternative splicing of cancer stem cell marker CD44 through a phosphorylated T179 of SMAD3-mediated interaction with RNA-binding protein PCBP1. We show that TGF-? and EGF respectively induce SMAD3 and PCBP1 to colocalize in SC35 positive nuclear speckles, and the two proteins interact in the variable exon region of CD44 pre-mRNA to inhibit spliceosome assembly in favor of expressing the mesenchymal isoform CD44s over the epithelial isoform CD44E. We further show that the SMAD3-mediated alternative splicing is essential to the tumor-promoting role of TGF-? and has a global influence on protein products of genes instrumental to epithelial to mesenchymal transition and metastasis. Twit Text FOAVip Direct regulation of alternative splicing by SMAD3 through PCBP1 is essential to the tumor-promoting role of TGF- ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=27746021 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27746021 #FOAvip English Wikipedia <ref>{{Cite pmid|27746021}}</ref> Direct regulation of alternative splicing by SMAD3 through PCBP1 is essential to the tumor-promoting role of TGF-? #MMPMID27746021 Tripathi V; Sixt KM; Gao S; Xu X; Huang J; Weigert R; Zhou M; Zhang YE Mol Cell 2016[Nov]; 64 (3): 549-64 PMID27746021show ga In advanced stages of cancers, TGF-? promotes tumor progression in conjunction with inputs from receptor tyrosine kinase pathways. However, mechanisms that underpin the signaling cooperation and convert TGF-? from a potent growth inhibitor to a tumor promoter are not fully understood. We report here that TGF-? directly regulates alternative splicing of cancer stem cell marker CD44 through a phosphorylated T179 of SMAD3-mediated interaction with RNA-binding protein PCBP1. We show that TGF-? and EGF respectively induce SMAD3 and PCBP1 to colocalize in SC35 positive nuclear speckles, and the two proteins interact in the variable exon region of CD44 pre-mRNA to inhibit spliceosome assembly in favor of expressing the mesenchymal isoform CD44s over the epithelial isoform CD44E. We further show that the SMAD3-mediated alternative splicing is essential to the tumor-promoting role of TGF-? and has a global influence on protein products of genes instrumental to epithelial to mesenchymal transition and metastasis. äDirect regulation of alternative splicing by SMAD3 through PCBP1 is es(epmc).pdf DeepDyve Pubget Overpricing