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10.1016/j.cell.2016.09.018 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.09.018 C5123704!5123704!27863239     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 167 (5): 1170-87 Nephropedia Template TP {{tp|p=27863239|t=2016. Ever-changing landscapes: transcriptional enhancers in development and evolution |pdf=|usr=}}{{27863239}} gab.com Text Ever-changing landscapes: transcriptional enhancers in development and evolution JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27863239 #FOAvip A class of cis-regulatory elements called enhancers plays a central role in orchestrating spatio-temporally precise gene expression programs during development. Consequently, divergence in enhancer sequence and activity is thought to be an important mediator of inter- and intra-species phenotypic variation. Here, we give an overview of emerging principles of enhancer function, current models of enhancer architecture, genomic substrates from which enhancers emerge during evolution and the influence of three-dimensional genome organization on long-range gene regulation. We discuss intricate relationships between distinct elements within complex regulatory landscapes and consider their potential impact on specificity and robustness of transcriptional regulation. Twit Text FOAVip Ever-changing landscapes: transcriptional enhancers in development and evolution ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27863239 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27863239 #FOAvip English Wikipedia <ref>{{Cite pmid|27863239}}</ref> Ever-changing landscapes: transcriptional enhancers in development and evolution #MMPMID27863239 Long HK; Prescott SL; Wysocka J Cell 2016[Nov]; 167 (5): 1170-87 PMID27863239show ga A class of cis-regulatory elements called enhancers plays a central role in orchestrating spatio-temporally precise gene expression programs during development. Consequently, divergence in enhancer sequence and activity is thought to be an important mediator of inter- and intra-species phenotypic variation. Here, we give an overview of emerging principles of enhancer function, current models of enhancer architecture, genomic substrates from which enhancers emerge during evolution and the influence of three-dimensional genome organization on long-range gene regulation. We discuss intricate relationships between distinct elements within complex regulatory landscapes and consider their potential impact on specificity and robustness of transcriptional regulation. äEver-changing landscapes: transcriptional enhancers in development and(epmc).pdf DeepDyve Pubget Overpricing