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10.1038/ncomms13565 http://scihub22266oqcxt.onion/10.1038/ncomms13565 C5123071!5123071 !27882936     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27882936 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 13565 Nephropedia Template TP {{tp|p=27882936 |t=2016. The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities |pdf=|usr=}}{{27882936 }} gab.com Text The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27882936 #FOAvip According to dogma, initiator caspases are activated through proximity-induced homodimerization, but some studies infer that during apoptosis caspase-9 may instead form a holoenzyme with the Apaf-1 apoptosome. Using several biochemical approaches, including a novel site-specific crosslinking technique, we provide the first direct evidence that procaspase-9 homodimerizes within the apoptosome, markedly increasing its avidity for the complex and inducing selective intramolecular cleavage at Asp-315. Remarkably, however, procaspase-9 could also bind via its small subunit to the NOD domain in Apaf-1, resulting in the formation of a heterodimer that more efficiently activated procaspase-3. Following cleavage, the intersubunit linker (and associated conformational changes) in caspase-9-p35/p12 inhibited its ability to form homo- and heterodimers, but feedback cleavage by caspase-3 at Asp-330 removed the linker entirely and partially restored activity to caspase-9-p35/p10. Thus, the apoptosome mediates the formation of caspase-9 homo- and heterodimers, both of which are impacted by cleavage and contribute to its overall function. Twit Text FOAVip The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27882936 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27882936 #FOAvip English Wikipedia <ref>{{Cite pmid|27882936 }}</ref> The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities #MMPMID27882936 Wu CC ; Lee S ; Malladi S ; Chen MD ; Mastrandrea NJ ; Zhang Z ; Bratton SB Nat Commun 2016[Nov]; 7 (ä): 13565 PMID27882936 show ga According to dogma, initiator caspases are activated through proximity-induced homodimerization, but some studies infer that during apoptosis caspase-9 may instead form a holoenzyme with the Apaf-1 apoptosome. Using several biochemical approaches, including a novel site-specific crosslinking technique, we provide the first direct evidence that procaspase-9 homodimerizes within the apoptosome, markedly increasing its avidity for the complex and inducing selective intramolecular cleavage at Asp-315. Remarkably, however, procaspase-9 could also bind via its small subunit to the NOD domain in Apaf-1, resulting in the formation of a heterodimer that more efficiently activated procaspase-3. Following cleavage, the intersubunit linker (and associated conformational changes) in caspase-9-p35/p12 inhibited its ability to form homo- and heterodimers, but feedback cleavage by caspase-3 at Asp-330 removed the linker entirely and partially restored activity to caspase-9-p35/p10. Thus, the apoptosome mediates the formation of caspase-9 homo- and heterodimers, both of which are impacted by cleavage and contribute to its overall function. |*Apoptosis [MESH] |Animals [MESH] |Apoptosomes/*metabolism [MESH] |Apoptotic Protease-Activating Factor 1/*metabolism [MESH] |Caspase 3/*metabolism [MESH] |Caspase 9/*metabolism [MESH] |Dimerization [MESH] |Mice [MESH] |Phosphotransferases/metabolism [MESH] |Protein Kinases/metabolism [MESH] |Sf9 Cells [MESH] |Spodoptera [MESH]The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterod(epmc).pdf DeepDyve Pubget Overpricing