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2016 ; 17
(1
): 189
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
High prevalence of non-steroidal anti-inflammatory drug use among acute kidney
injury survivors in the southern community cohort study
#MMPMID27881100
Lipworth L
; Abdel-Kader K
; Morse J
; Stewart TG
; Kabagambe EK
; Parr SK
; Birdwell KA
; Matheny ME
; Hung AM
; Blot WJ
; Ikizler TA
; Siew ED
BMC Nephrol
2016[Nov]; 17
(1
): 189
PMID27881100
show ga
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and
have been linked to acute kidney injury (AKI), chronic kidney disease (CKD) and
cardiovascular disease (CVD). Patients who survive an AKI episode are at risk for
future adverse kidney and cardiovascular outcomes. The objective of our study was
to examine the prevalence and predictors of NSAID use among AKI survivors.
METHODS: The Southern Community Cohort Study is a prospective study of low-income
adults aged 40-79 in the southeastern US. Through linkage with Centers for
Medicare and Medicaid Services, 826 participants with an AKI diagnosis (ICD-9
584.5-584.9) at any age prior to cohort enrollment were identified. At baseline,
data were collected on regular use of prescription and over-the-counter NSAIDs,
as well as demographic, medical and other characteristics. Additional
comorbidities were ascertained via linkage with CMS or the US Renal Data System.
RESULTS: One hundred fifty-four AKI survivors (19%) reported regular NSAID use at
cohort enrollment (52 prescription, 81 OTC, 21 both) and the percentage of NSAID
users did not vary by time since AKI event. Over 58% of users were taking NSAIDS
regularly both before and after their AKI event. Hypertension (83%), arthritis
(71%), heart failure (44%), CKD (36%) and diabetes (35%) were prevalent among
NSAID users. In a multivariable model, history of arthritis (OR: 3.00; 95% CI:
1.92, 4.68) and acetaminophen use (OR: 2.43; 95% CI: 1.50, 3.93) were
significantly associated with NSAID use, while prevalent CKD (OR: 0.63; 95% CI:
0.41, 0.98) and diabetes (OR: 0.44; 95% CI: 0.29, 0.69) were significantly
inversely associated. CONCLUSIONS: NSAID use among AKI survivors is common and
highlights the need to understand physician and patient decision-making around
NSAIDs and to develop effective strategies to reduce NSAID use in this vulnerable
population.