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10.1016/j.devcel.2016.09.014 http://scihub22266oqcxt.onion/10.1016/j.devcel.2016.09.014 C5121078!5121078!27746045     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Cell 2016 ; 39 (4): 438-51 Nephropedia Template TP {{tp|p=27746045|t=2016. Regulation of Smoothened trafficking and Hedgehog signaling by the SUMO pathway |pdf=|usr=}}{{27746045}} gab.com Text Regulation of Smoothened trafficking and Hedgehog signaling by the SUMO pathway JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=27746045 #FOAvip Hedgehog (Hh) signaling plays a central role in development and diseases. Hh activates its signal transducer and GPCR-family protein Smoothened (Smo) by inducing Smo phosphorylation but whether Smo is activated through other post-translational modifications remains unexplored. Here we show that sumoylation acts in parallel with phosphorylation to promote Smo cell surface expression and Hh signaling. We find that Hh stimulates Smo sumoylation by dissociating it from a de-sumoylation enzyme Ulp1. Sumoylation of Smo in turn recruits a deubiquitinase UBPY/USP8 to antagonize Smo ubiquitination and degradation, leading to its cell surface accumulation and elevated Hh pathway activity. We also provide evidence that Shh stimulates sumoylation of mammalian Smo (mSmo) and that sumoylation promotes ciliary localization of mSmo and Shh pathway activity. Our findings reveal a conserved mechanism whereby the SUMO pathway promotes Hh signaling by regulating Smo subcellular localization and shed light on how sumoylation regulates membrane protein trafficking. Twit Text FOAVip Regulation of Smoothened trafficking and Hedgehog signaling by the SUMO pathway ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=27746045 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27746045 #FOAvip English Wikipedia <ref>{{Cite pmid|27746045}}</ref> Regulation of Smoothened trafficking and Hedgehog signaling by the SUMO pathway #MMPMID27746045 Ma G; Li S; Han Y; Li S; Yue T; Wang B; Jiang J Dev Cell 2016[Nov]; 39 (4): 438-51 PMID27746045show ga Hedgehog (Hh) signaling plays a central role in development and diseases. Hh activates its signal transducer and GPCR-family protein Smoothened (Smo) by inducing Smo phosphorylation but whether Smo is activated through other post-translational modifications remains unexplored. Here we show that sumoylation acts in parallel with phosphorylation to promote Smo cell surface expression and Hh signaling. We find that Hh stimulates Smo sumoylation by dissociating it from a de-sumoylation enzyme Ulp1. Sumoylation of Smo in turn recruits a deubiquitinase UBPY/USP8 to antagonize Smo ubiquitination and degradation, leading to its cell surface accumulation and elevated Hh pathway activity. We also provide evidence that Shh stimulates sumoylation of mammalian Smo (mSmo) and that sumoylation promotes ciliary localization of mSmo and Shh pathway activity. Our findings reveal a conserved mechanism whereby the SUMO pathway promotes Hh signaling by regulating Smo subcellular localization and shed light on how sumoylation regulates membrane protein trafficking. äRegulation of Smoothened trafficking and Hedgehog signaling by the SUM(epmc).pdf DeepDyve Pubget Overpricing