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10.1016/j.ijpharm.2016.07.002 http://scihub22266oqcxt.onion/10.1016/j.ijpharm.2016.07.002 C5120990!5120990 !27863666     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27863666 &cmd=llinks): Failed to open stream: HTTP request failed! 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Nasal powders of thalidomide for local treatment of nose bleeding in persons affected by hereditary hemorrhagic telangiectasia |pdf=|usr=}}{{27863666 }} gab.com Text Nasal powders of thalidomide for local treatment of nose bleeding in persons affected by hereditary hemorrhagic telangiectasia JO: Int J Pharm http://www.kidney.de/pget.php?&tw=1&pmid=27863666 #FOAvip In this work nasal powder formulations of thalidomide were designed and studied to be used by persons affected by hereditary hemorrhagic telangiectasia as a complementary anti-epistaxis therapy, with the goal of sustaining the effect obtained with thalidomide oral treatment after its discontinuation for adverse effects. Three nasal powders were prepared using as carriers ?-CD or its more hydrophilic derivatives such as hydropropyl-?-CD and sulphobutylether-?-CD and tested with respect to technological and biopharmaceutical features after emission with active and passive nasal powder devices. For all formulated powders, improved dissolution rate was found compared to that of the raw material, making thalidomide promptly available in the nasal environment at a concentration favouring an accumulation in the mucosa. The very limited transmucosal transport measured in vitro suggests a low likelihood of significant systemic absorption. The topical action on bleeding could benefit from the poor absorption and from the fact that about 2-3% of the thalidomide applied on the nasal mucosa was accumulated within the tissue, particularly with the ?-CD nasal powder. Twit Text FOAVip Nasal powders of thalidomide for local treatment of nose bleeding in persons affected by hereditary hemorrhagic telangiectasia ????Int J Pharm http://www.kidney.de/pget.php?&tw=1&pmid=27863666 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27863666 #FOAvip English Wikipedia <ref>{{Cite pmid|27863666 }}</ref> Nasal powders of thalidomide for local treatment of nose bleeding in persons affected by hereditary hemorrhagic telangiectasia #MMPMID27863666 Colombo G ; Bortolotti F ; Chiapponi V ; Buttini F ; Sonvico F ; Invernizzi R ; Quaglia F ; Danesino C ; Pagella F ; Russo P ; Bettini R ; Colombo P ; Rossi A Int J Pharm 2016[Nov]; 514 (1 ): 229-237 PMID27863666 show ga In this work nasal powder formulations of thalidomide were designed and studied to be used by persons affected by hereditary hemorrhagic telangiectasia as a complementary anti-epistaxis therapy, with the goal of sustaining the effect obtained with thalidomide oral treatment after its discontinuation for adverse effects. Three nasal powders were prepared using as carriers ?-CD or its more hydrophilic derivatives such as hydropropyl-?-CD and sulphobutylether-?-CD and tested with respect to technological and biopharmaceutical features after emission with active and passive nasal powder devices. For all formulated powders, improved dissolution rate was found compared to that of the raw material, making thalidomide promptly available in the nasal environment at a concentration favouring an accumulation in the mucosa. The very limited transmucosal transport measured in vitro suggests a low likelihood of significant systemic absorption. The topical action on bleeding could benefit from the poor absorption and from the fact that about 2-3% of the thalidomide applied on the nasal mucosa was accumulated within the tissue, particularly with the ?-CD nasal powder. |Administration, Intranasal [MESH] |Animals [MESH] |Chemistry, Pharmaceutical/methods [MESH] |Drug Carriers/chemistry [MESH] |Epistaxis/*drug therapy [MESH] |Humans [MESH] |Nasal Mucosa/drug effects [MESH] |Powders/*administration & dosage [MESH] |Rabbits [MESH] |Solubility [MESH] |Telangiectasia, Hereditary Hemorrhagic/*drug therapy [MESH] |Thalidomide/*administration & dosage [MESH]Nasal powders of thalidomide for local treatment of nose bleeding in p(epmc).pdf DeepDyve Pubget Overpricing