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10.1080/19491034.2016.1238998 http://scihub22266oqcxt.onion/10.1080/19491034.2016.1238998 C5120600!5120600 !27673560     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27673560 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleus 2016 ; 7 (5 ): 462-475 Nephropedia Template TP {{tp|p=27673560 |t=2016. A potential role for genome structure in the translation of mechanical force during immune cell development |pdf=|usr=}}{{27673560 }} gab.com Text A potential role for genome structure in the translation of mechanical force during immune cell development JO: Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=27673560 #FOAvip Immune cells react to a wide range of environments, both chemical and physical. While the former has been extensively studied, there is growing evidence that physical and in particular mechanical forces also affect immune cell behavior and development. In order to elicit a response that affects immune cell behavior or development, environmental signals must often reach the nucleus. Chemical and mechanical signals can initiate signal transduction pathways, but mechanical forces may also have a more direct route to the nucleus, altering nuclear shape via mechanotransduction. The three-dimensional organization of DNA allows for the possibility that altering nuclear shape directly remodels chromatin, redistributing critical regulatory elements and proteins, and resulting in wide-scale gene expression changes. As such, integrating mechanotransduction and genome architecture into the immunology toolkit will improve our understanding of immune development and disease. Twit Text FOAVip A potential role for genome structure in the translation of mechanical force during immune cell development ????Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=27673560 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27673560 #FOAvip English Wikipedia <ref>{{Cite pmid|27673560 }}</ref> A potential role for genome structure in the translation of mechanical force during immune cell development #MMPMID27673560 Jacobson E ; Perry JK ; Long DS ; Vickers MH ; O'Sullivan JM Nucleus 2016[Sep]; 7 (5 ): 462-475 PMID27673560 show ga Immune cells react to a wide range of environments, both chemical and physical. While the former has been extensively studied, there is growing evidence that physical and in particular mechanical forces also affect immune cell behavior and development. In order to elicit a response that affects immune cell behavior or development, environmental signals must often reach the nucleus. Chemical and mechanical signals can initiate signal transduction pathways, but mechanical forces may also have a more direct route to the nucleus, altering nuclear shape via mechanotransduction. The three-dimensional organization of DNA allows for the possibility that altering nuclear shape directly remodels chromatin, redistributing critical regulatory elements and proteins, and resulting in wide-scale gene expression changes. As such, integrating mechanotransduction and genome architecture into the immunology toolkit will improve our understanding of immune development and disease. |Animals [MESH] |Cell Differentiation [MESH] |Cell Shape [MESH] |Genome/*genetics [MESH] |Humans [MESH] |Immunity/*genetics [MESH] |Mechanotransduction, Cellular/*genetics/*immunology [MESH]A potential role for genome structure in the translation of mechanical(epmc).pdf DeepDyve Pubget Overpricing