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10.1080/19491034.2016.1248013 http://scihub22266oqcxt.onion/10.1080/19491034.2016.1248013 C5120593!5120593!27759487     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleus 2016 ; 7 (5): 447-52 Nephropedia Template TP {{tp|p=27759487|t=2016. Crosstalk between pluripotency factors and higher-order chromatin organization |pdf=|usr=}}{{27759487}} gab.com Text Crosstalk between pluripotency factors and higher-order chromatin organization JO: Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=27759487 #FOAvip Pluripotent cells are characterized by a globally open and accessible chromatin organization that is thought to contribute to cellular plasticity and developmental decision-making. We recently identified the pluripotency factor Nanog as a key regulator of this form of chromatin architecture in mouse embryonic stem cells. In particular, we demonstrated that the transcription factors Nanog and Sall1 co-dependently mediate the epigenetic state of pericentromeric heterochromatin to reinforce a more open and accessible organization in pluripotent cells. Here, we summarize our main findings and place the work into a broader context. We explore how heterochromatin domains could be targets of transcriptional networks in pluripotent cells and are coordinated with cell state. We propose this integration may be to balance the requirement for a dynamic and plastic chromatin organization in pluripotent cells, together with priming for a more restrictive nuclear compartmentalization that is triggered rapidly upon lineage commitment. Twit Text FOAVip Crosstalk between pluripotency factors and higher-order chromatin organization ????Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=27759487 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27759487 #FOAvip English Wikipedia <ref>{{Cite pmid|27759487}}</ref> Crosstalk between pluripotency factors and higher-order chromatin organization #MMPMID27759487 Lopes Novo C; Rugg-Gunn P Nucleus 2016[]; 7 (5): 447-52 PMID27759487show ga Pluripotent cells are characterized by a globally open and accessible chromatin organization that is thought to contribute to cellular plasticity and developmental decision-making. We recently identified the pluripotency factor Nanog as a key regulator of this form of chromatin architecture in mouse embryonic stem cells. In particular, we demonstrated that the transcription factors Nanog and Sall1 co-dependently mediate the epigenetic state of pericentromeric heterochromatin to reinforce a more open and accessible organization in pluripotent cells. Here, we summarize our main findings and place the work into a broader context. We explore how heterochromatin domains could be targets of transcriptional networks in pluripotent cells and are coordinated with cell state. We propose this integration may be to balance the requirement for a dynamic and plastic chromatin organization in pluripotent cells, together with priming for a more restrictive nuclear compartmentalization that is triggered rapidly upon lineage commitment. äCrosstalk between pluripotency factors and higher-order chromatin orga(epmc).pdf DeepDyve Pubget Overpricing