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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ann+Occup+Environ+Med
2016 ; 28
(ä): 67
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Urinary arsenic species concentration in residents living near abandoned metal
mines in South Korea
#MMPMID27895924
Chung JY
; Kim BG
; Lee BK
; Moon JD
; Sakong J
; Jeon MJ
; Park JD
; Choi BS
; Kim NS
; Yu SD
; Seo JW
; Ye BJ
; Lim HJ
; Hong YS
Ann Occup Environ Med
2016[]; 28
(ä): 67
PMID27895924
show ga
BACKGROUND: Arsenic is a carcinogenic heavy metal that has a species-dependent
health effects and abandoned metal mines are a source of significant arsenic
exposure. Therefore, the aims of this study were to analyze urinary arsenic
species and their concentration in residents living near abandoned metal mines
and to monitor the environmental health effects of abandoned metal mines in
Korea. METHODS: This study was performed in 2014 to assess urinary arsenic
excretion patterns of residents living near abandoned metal mines in South Korea.
Demographic data such as gender, age, mine working history, period of residency,
dietary patterns, smoking and alcohol use, and type of potable water consumed
were obtaining using a questionnaire. Informed consent was also obtained from all
study subjects (n?=?119). Urinary arsenic species were quantified using high
performance liquid chromatography (HPLC) and inductively coupled plasma mass
spectrometry (ICP/MS). RESULTS: The geometric mean of urinary arsenic (sum of
dimethylarsinic acid, monomethylarsonic acid, As(3+), and As(5+)) concentration
was determined to be 131.98 ?g/L (geometric mean; 95% CI, 116.72-149.23) while
urinary inorganic arsenic (As(3+) and As(5+)) concentration was 0.81 ?g/L (95%
CI, 0.53-1.23). 66.3% (n?=?79) and 21.8% (n?=?26) of these samples exceeded ATSDR
reference values for urinary arsenic (>100 ?g/L) and inorganic arsenic
(>10 ?g/L), respectively. Mean urinary arsenic concentrations (geometric mean,
GM) were higher in women then in men, and increased with age. Of the five regions
evaluated, while four regions had inorganic arsenic concentrations less than
0.40 ?g/L, one region showed a significantly higher concentration (GM 15.48 ?g/L;
95% CI, 7.51-31.91) which investigates further studies to identify etiological
factors. CONCLUSION: We propose that the observed elevation in urinary arsenic
concentration in residents living near abandoned metal mines may be due to
environmental contamination from the abandoned metal mine. TRIAL REGISTRATION:
Not Applicable (We do not have health care intervention on human participants).