Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27896241
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nephrourol+Mon
2016 ; 8
(6
): e40409
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Local Administration of Tranexamic Acid During Prostatectomy Surgery: Effects on
Reducing the Amount of Bleeding
#MMPMID27896241
Pourfakhr P
; Gatavi E
; Gooran S
; Etezadi F
; Khajavi MR
; Pourroustaei R
; Shariat Moharari R
; Najafi A
Nephrourol Mon
2016[Nov]; 8
(6
): e40409
PMID27896241
show ga
BACKGROUND: One of the issues in prostatectomy surgery is bleeding. Although
tranexamic acid (TRA) is an antifibrinolytic agent for reducing bleeding,
controversies surround its use. OBJECTIVES: In this study, the effect of local
administration of TRA on reducing bleeding during prostatectomy surgery was
evaluated. METHODS: A total of 186 patients who underwent prostatectomy surgery
were assessed in this clinical trial study. Patients were divided randomly into
two groups. After prostate removal, TRA (500 mg TRA with 5 mL total volume) to
the intervention group and normal saline to the control group were sprayed with
the same volume. At the end of surgery, the prescribed blood bags were measured
and recorded. Hemoglobin and platelet levels were recorded 6 hours after the
test. Moreover, the amounts of blood inside the blood bags in the first 24 hours,
the second 24 hours, and the total length of hospital stay were recorded and
compared in each group. RESULTS: By comparing the measured values before and
after surgery, we found that the amounts of hemoglobin, hematocrit, and platelet
decreased. The mean blood loss in the intervention group was recorded at 340 mL
and that in the control group was 515 mL. The maximum bleeding in the control
group was almost twice as much as that in the intervention group. Blood loss in
the intervention group with the administration of TRA was significantly lesser
than that in the control group (P = 0.01). The decrease in platelet level in the
intervention group was significantly lower than that in the control group (P =
0.03). CONCLUSIONS: The present study showed that local administration of TRA
significantly reduces bleeding after prostatectomy surgery and is effective in
preventing postoperative hemoglobin decrease.