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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Immunol+Res
2016 ; 2016
(ä): 6540937
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Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in
Patients with IgA Nephropathy
#MMPMID27900334
Zhang Z
; Wang H
; Zhang L
; Crew R
; Zhang N
; Liu X
; Jiang Y
J Immunol Res
2016[]; 2016
(ä): 6540937
PMID27900334
show ga
Background. The IL-33/ST2 axis is involved in humoral immune responses. Method.
The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls
(HC) were measured by ELISA. Clinical and laboratory data were examined. The
potential association between sera IL-33 and sST2 and the clinical parameters in
IgAN patients were analyzed. Results. No difference was discovered in IL-33
concentrations between IgAN patients and HCs; however, the sST2 were
significantly higher in each stage of IgAN progression than in the HC. The
concentration of sST2 was positively correlated with IL-33 levels in IgAN
patients. Higher levels of sera IL-2, IL-4, IL-10, IL-17A, and IFN-? were
detected in patients compared to the HC. The concentration of serum sST2 was
positively correlated with the levels of IL-10 in IgAN patients. Furthermore,
serum sST2 was negatively correlated with the values of eGFR and serum calcium.
Serum sST2 was positively correlated with 24-hour urinary protein, serum
phosphorus, and serum IgA; however, serum IL-33 was not associated with these.
Following treatment, serum sST2 was significantly decreased, while sera IL-4 and
IL-10 were significantly increased. Conclusions. Increased sST2 and IL-10 but not
IL-33 may be involved in the pathogenic process of IgAN.