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10.1155/2016/6540937

http://scihub22266oqcxt.onion/10.1155/2016/6540937
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C5120178!5120178 !27900334
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suck abstract from ncbi


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pmid27900334
      J+Immunol+Res 2016 ; 2016 (ä): 6540937
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  • Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy #MMPMID27900334
  • Zhang Z ; Wang H ; Zhang L ; Crew R ; Zhang N ; Liu X ; Jiang Y
  • J Immunol Res 2016[]; 2016 (ä): 6540937 PMID27900334 show ga
  • Background. The IL-33/ST2 axis is involved in humoral immune responses. Method. The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls (HC) were measured by ELISA. Clinical and laboratory data were examined. The potential association between sera IL-33 and sST2 and the clinical parameters in IgAN patients were analyzed. Results. No difference was discovered in IL-33 concentrations between IgAN patients and HCs; however, the sST2 were significantly higher in each stage of IgAN progression than in the HC. The concentration of sST2 was positively correlated with IL-33 levels in IgAN patients. Higher levels of sera IL-2, IL-4, IL-10, IL-17A, and IFN-? were detected in patients compared to the HC. The concentration of serum sST2 was positively correlated with the levels of IL-10 in IgAN patients. Furthermore, serum sST2 was negatively correlated with the values of eGFR and serum calcium. Serum sST2 was positively correlated with 24-hour urinary protein, serum phosphorus, and serum IgA; however, serum IL-33 was not associated with these. Following treatment, serum sST2 was significantly decreased, while sera IL-4 and IL-10 were significantly increased. Conclusions. Increased sST2 and IL-10 but not IL-33 may be involved in the pathogenic process of IgAN.
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Biomarkers [MESH]
  • |Cytokines/blood [MESH]
  • |Female [MESH]
  • |Glomerulonephritis, IGA/*blood/*diagnosis/drug therapy/immunology [MESH]
  • |Humans [MESH]
  • |Immunosuppressive Agents/administration & dosage/therapeutic use [MESH]
  • |Interleukin-1 Receptor-Like 1 Protein/*blood [MESH]
  • |Interleukin-10/*blood [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Prognosis [MESH]
  • |Severity of Illness Index [MESH]
  • |Treatment Outcome [MESH]


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