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10.1002/cam4.871 http://scihub22266oqcxt.onion/10.1002/cam4.871 C5119990!5119990!27734632     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27734632&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Med 2016 ; 5 (11): 3353-67 Nephropedia Template TP {{tp|p=27734632|t=2016. Is there a role for IGF?1 in the development of second primary cancers?|pdf=|usr=}}{{27734632}} gab.com Text Is there a role for IGF 1 in the development of second primary cancers JO: Cancer Med http://www.kidney.de/pget.php?&tw=1&pmid=27734632 #FOAvip Cancer survival rates are increasing, and as a result, more cancer survivors are exposed to the risk of developing a second primary cancer (SPC). It has been hypothesized that one of the underlying mechanisms for this risk could be mediated by variations in insulin?like growth factor?1 (IGF?1). This review summarizes the current epidemiological evidence to identify whether IGF?1 plays a role in the development of SPCs. IGF?1 is known to promote cancer development by inhibiting apoptosis and stimulating cell proliferation. Epidemiological studies have reported a positive association between circulating IGF?1 levels and various primary cancers, such as breast, colorectal, and prostate cancer. The role of IGF?1 in increasing SPC risk has been explored less. Nonetheless, several experimental studies have observed a deregulation of the IGF?1 pathway, which may explain the association between IGF?1 and SPCs. Thus, measuring serum IGF?1 may serve as a useful marker in assessing the risk of SPCs, and therefore, more translational experimental and epidemiological studies are needed to further disentangle the role of IGF?1 in the development of specific SPCs. Twit Text FOAVip Is there a role for IGF 1 in the development of second primary cancers ????Cancer Med http://www.kidney.de/pget.php?&tw=1&pmid=27734632 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27734632 #FOAvip English Wikipedia <ref>{{Cite pmid|27734632}}</ref> Is there a role for IGF?1 in the development of second primary cancers? #MMPMID27734632 Shanmugalingam T; Bosco C; Ridley AJ; Van Hemelrijck M Cancer Med 2016[Nov]; 5 (11): 3353-67 PMID27734632show ga Cancer survival rates are increasing, and as a result, more cancer survivors are exposed to the risk of developing a second primary cancer (SPC). It has been hypothesized that one of the underlying mechanisms for this risk could be mediated by variations in insulin?like growth factor?1 (IGF?1). This review summarizes the current epidemiological evidence to identify whether IGF?1 plays a role in the development of SPCs. IGF?1 is known to promote cancer development by inhibiting apoptosis and stimulating cell proliferation. Epidemiological studies have reported a positive association between circulating IGF?1 levels and various primary cancers, such as breast, colorectal, and prostate cancer. The role of IGF?1 in increasing SPC risk has been explored less. Nonetheless, several experimental studies have observed a deregulation of the IGF?1 pathway, which may explain the association between IGF?1 and SPCs. Thus, measuring serum IGF?1 may serve as a useful marker in assessing the risk of SPCs, and therefore, more translational experimental and epidemiological studies are needed to further disentangle the role of IGF?1 in the development of specific SPCs. äIs there a role for IGF?1 in the development of second primary cancers(epmc).pdf DeepDyve Pubget Overpricing