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2016 ; 5
(11
): 3051-3058
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Clinical significance of granule-containing myeloma cells in patients with newly
diagnosed multiple myeloma
#MMPMID27734595
Suzuki K
; Yano S
; Nishiwaki K
; Sano K
; Shimada T
; Yahagi Y
; Ogasawara Y
; Sugiyama K
; Takahara S
; Saito T
; Kasama K
; Minami J
; Yokoyama H
; Kamiyama Y
; Katsube A
; Masuoka H
; Katori M
; Machishima T
; Ouchi A
; Dobashi N
; Kaito K
; Usui N
; Aiba K
Cancer Med
2016[Nov]; 5
(11
): 3051-3058
PMID27734595
show ga
The clinical features and prognostic significance of myeloma cells containing
granules remain unclear. The purpose of this retrospective study was to
investigate the clinical significance of granule-containing myeloma cells in
patients with newly diagnosed multiple myeloma (NDMM). We retrospectively
analyzed the records of 122 patients diagnosed with NDMM between January 2007 and
December 2013. Granule-containing myeloma cells were defined as myeloma cells
that exhibited three or more granules in their cytoplasm by May-Giemsa staining.
The patients were classified into two groups, the granule-containing myeloma (GM)
and nongranule-containing myeloma (non-GM) groups, depending on the proportion of
myeloma cells that contained granules (cut-off value: 10%). There were 25 (20.5%)
patients in the GM group. Patients in the GM group displayed significantly higher
CD56 and CD49e expression than those in the non-GM group (t-test, P = 0.027 and
0.042). None of the patient characteristics differed significantly between the
two groups. There was no significant difference in the chemotherapy profiles of
the two groups, and the overall response rates of the two groups were similar.
During the median follow-up period of 33.9 months, the overall survival (OS) in
the GM group was similar to that in the non-GM group; 4-year OS of the GM and
non-GM groups were 78.5% and 51.9%, respectively (P = 0.126). We concluded that
cases of NDMM involving granule-containing myeloma cells are not infrequent.
Moreover, CD56 and CD49e expression was significantly higher in the presence of
myeloma cell populations, and the presence of granules did not affect survival.
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