Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4137/CPath.S39930 http://scihub22266oqcxt.onion/10.4137/CPath.S39930 C5119657!5119657!27891058     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Med+Insights+Pathol 2016 ; 9 (Suppl 1): 21-8 Nephropedia Template TP {{tp|p=27891058|t=2016. IDO2: A Pathogenic Mediator of Inflammatory Autoimmunity |pdf=|usr=}}{{27891058}} gab.com Text IDO2: A Pathogenic Mediator of Inflammatory Autoimmunity JO: Clin Med Insights Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27891058 #FOAvip Indoleamine 2,3-dioxygenase 2 (IDO2), a homolog of the better-studied tryptophan-catabolizing enzyme IDO1, is an immunomodulatory molecule with potential effects on various diseases including cancer and autoimmunity. Here, we review what is known about the direct connections between IDO2 and immune function, particularly in relationship to autoimmune inflammatory disorders such as rheumatoid arthritis and lupus. Accumulating evidence indicates that IDO2 acts as a pro-inflammatory mediator of autoimmunity, with a functional phenotype distinct from IDO1. IDO2 is expressed in antigen-presenting cells, including B cells and dendritic cells, but affects inflammatory responses in the autoimmune context specifically by acting in B cells to modulate T cell help in multiple model systems. Given that expression of IDO2 can lead to exacerbation of inflammatory responses, IDO2 should be considered a potential therapeutic target for autoimmune disorders. Twit Text FOAVip IDO2: A Pathogenic Mediator of Inflammatory Autoimmunity ????Clin Med Insights Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27891058 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27891058 #FOAvip English Wikipedia <ref>{{Cite pmid|27891058}}</ref> IDO2: A Pathogenic Mediator of Inflammatory Autoimmunity #MMPMID27891058 Merlo LM; Mandik-Nayak L Clin Med Insights Pathol 2016[]; 9 (Suppl 1): 21-8 PMID27891058show ga Indoleamine 2,3-dioxygenase 2 (IDO2), a homolog of the better-studied tryptophan-catabolizing enzyme IDO1, is an immunomodulatory molecule with potential effects on various diseases including cancer and autoimmunity. Here, we review what is known about the direct connections between IDO2 and immune function, particularly in relationship to autoimmune inflammatory disorders such as rheumatoid arthritis and lupus. Accumulating evidence indicates that IDO2 acts as a pro-inflammatory mediator of autoimmunity, with a functional phenotype distinct from IDO1. IDO2 is expressed in antigen-presenting cells, including B cells and dendritic cells, but affects inflammatory responses in the autoimmune context specifically by acting in B cells to modulate T cell help in multiple model systems. Given that expression of IDO2 can lead to exacerbation of inflammatory responses, IDO2 should be considered a potential therapeutic target for autoimmune disorders. äIDO2: A Pathogenic Mediator of Inflammatory Autoimmunity (epmc).pdf DeepDyve Pubget Overpricing