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suck abstract from ncbi


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pmid27100703      Front+Biosci+(Schol+Ed) 2016 ; 8 (ä): 215-26
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  • Interaction of the renin angiotensin and cox systems in the kidney #MMPMID27100703
  • Quadri SS; Culver SA; Li C; Siragy HM
  • Front Biosci (Schol Ed) 2016[Jun]; 8 (ä): 215-26 PMID27100703show ga
  • Cyclooxygenase-2 (COX-2) plays an important role in mediating actions of the renin-angiotensin system (RAS). This review sheds light on the recent developments regarding the complex interactions between components of RAS and COX-2; and their implications on renal function and disease. COX-2 is believed to counter regulate the effects of RAS activation and therefore counter balance the vasoconstriction effect of Ang II. In kidney, under normal conditions, these systems are essential for maintaining a balance between vasodilation and vasoconstriction. However, recent studies suggested a pivotal role for this interplay in pathology. COX-2 increases the renin release and Ang II formation leading to increase in blood pressure. COX-2 is also associated with diabetic nephropathy, where its upregulation in the kidney contributes to glomerular injury and albuminuria. Selective inhibition of COX-2 retards the progression of renal injury. COX-2 also mediates the pathologic effects of the (Pro)renin receptor (PRR) in the kidney. In summary, this review discusses the interaction between the RAS and COX-2 in health and disease.
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